Sulphanilamide inhibition of the growth of certain yeasts and yeastlike organisms was overcome in a non-competitive manner by methionine, adenine and histidine, which are therefore regarded as end-products of enzyme systems for which p-aminobenzoic acid is essential. The methionine system was the most sensitive to sulphanilamide, followed in order by those of adenine and histidine. In the prese...

The in vivo acetylator phenotype as well as N-acetyltransferase (NAT) and O-acetyltransferase (OAT) activities in cytosols from cultured uroepithelia were determined in 25 urological patients. In vivo acetylator phenotypes were categorized by determining the amounts of 5-acetylamino-6-formylamino-3-methyluracil (AFMU) and 1-methylxanthine in urine after the administration of a 200 mg dose of ca...

In this investigation, an amino functionalized adsorbent was developed by grafting 4-aminobenzoic acid onto the backbone of cross-linked chitosan beads. The 3 sets of beads including chitosan (CX), glutaraldehyde cross-linked chitosan (CCX), and 4-aminobenzoic acid grafted cross-linked chitosan (FGCX) were characterized by FTIR, XRD, SEM, and TGA. The water content and amine concentration of FG...

A basis for understanding the mode of action of sulfonamide drugs in terms of the WoodsFildes theory of antagonism (Woods, 1940; Fildes, 1940) was provided by the elucidation of the structure of folic acid (Stokstad et al., 1946; Angier et al., 1946; Mowat et al., 1948). Since folic acid contains a p-aminobenzoic acid moiety, it was postulated that the structurally similar sulfonamides compete ...

Being impermeable to folic acid, many bacteria must rely on their ability to synthesise folate from PABA, Pteridine, and glutamate in contrast the mammalian in cells cannot synthesise folic acid and must obtain preformed folate as a vitamin in their diet. The sulphonamides are structurally similar to PABA, the sulphonamides competitively inhibit dihydropteroate synthetase, the enzyme that catal...

To identify steps in fungal intermediary metabolism required by Aspergillus spp. during invasive pulmonary aspergillosis, we have developed murine models involving Aspergillus nidulans as the inoculum. The advantages of using A. nidulans over Aspergillus fumigatus or Aspergillus flavus, which are the most common agents of clinical disease, are the well-understood genetics of A. nidulans and a l...