Doxorubicin is a chemotherapeutic drug used as a cure for cancer. Being an anthracycline antibiotic, it is commonly used in treating a wide varieties of cancers. In this report, the molecular structure, Binding Energy(BE), Dipole Moment (DM), Gibbs free energy of solvation (ΔG(solvation)) and some physicochemical properties of Doxorubicin were conjugated chemically to the terminal end of a di-b...

Abstract Introduction Non-surgical / minimally invasive aesthetic procedures are a growing trend in the UK. A range of devices available for soft tissue augmentation, including injectable Poly-L-Lactic acid (PLLA). PLLA is used augmentation and thought effective correction contour deficiencies, facial wrinkles restoring subcutaneous volume patients with HIV-associated lipoatrophy. Method In thi...

BACKGROUND Star-shaped polymers provide more terminal groups, and are promising for application in drug-delivery systems. METHODS A new series of six-arm star-shaped poly(lactic-co-glycolic acid) (6-s-PLGA) was synthesized by ring-opening polymerization. The structure and properties of the 6-s-PLGA were characterized by carbon-13 nuclear magnetic resonance spectroscopy, infrared spectroscopy,...

This work describes a novel L-lactate biosensor based on the immobilization of dehydrogenase enzyme screen-printed electrode modified with ternary composite gold nanoparticles, electrochemically-reduced graphene oxide, and poly (allylamine hydrochloride). The was stabilized by crosslinking glutaraldehyde. Applied working potential, pH NAD+ concentration were optimized. reports specific sensitiv...

Bevacizumab (Avastin(®)) has been used by ophthalmologists in many countries as an off-label drug for the treatment of wet age-related macular degeneration (AMD). Due to its short half-life necessitating frequent intravitreal injection, a method for sustained delivery is in need. We demonstrated that bevacizumab could be released in a sustained fashion over 90 days from nano- and microspheres f...

In guided bone regeneration (GBR), a barrier membrane is applied to provide space for promote cell adhesion, proliferation, and by inducing migration the surface of bone-deficient site. We prepared non-woven absorbable GBR comprised copolymer L-lactic acid glycolic (PLLGA) using dry spinning method. A thin dense comprising unsintered hydroxyapatite (uHA) poly-L-lactic (PLLA) was used comparison...

A green approach is proposed to achieve a rapid surface functionalization of microcrystalline cellulose (MCC) in 30 min by solvent-free "grafting from" reaction l-lactide through compression molding without the need for an inert atmosphere. sufficient hydrophobization MCC achieved with amount grafted poly(l-lactic acid) (PLLA) oligomers 7 wt % respect MCC. The obtained MCC-g-PLLA subsequently m...