Graphene oxides (GOs) with different surface characteristics, such as size, reduction degree and charge, are prepared, and their effects on the specificity of polymerase chain reaction (PCR) are investigated. In this study, we demonstrate that GO with a large size and high reduction degree is superior to small and nonreduced GO in enhancing the specificity of PCR. Negatively charged polyacrylic...

A method to carry out the linear polymerization of a synthetic peptide using acetamidomethyl (Acm)-protected thiol groups of cysteine residues, was developed. This polymer showed to be useful in the improvement of peptide immunogenicity. To achieve the polymerization, two Cys(Acm) residues were incorporated at both ends of the peptide. The model peptide contains B and T cell epitopes placed in ...

Laboratory column experiments were conducted to study the effects of anionic polyacrylamide (PAM) polymer and surfactant linear alkylbenzene sulfonate (LAS) on the movement of Escherichia coli and the FRNA phage MS-2. The study was designed to evaluate if PAM or PAM + LAS would enhance the mobility of human pathogens in tropical soils under unsaturated conditions. No breakthrough of phage was o...

Title of Document: MICROFLUIDICS INTERFACING TO MASS SPECTROMETRY YI ZHOU, Doctor of Philosophy, 2007 Directed By: Dr. Don L. Devoe, Associate Professor, Department of Mechanical Engineering Polymer-based microfluidic systems have received considerable attention for high throughput chemical analysis. Recently, the ongoing development of microfluidics interfacing to high-accuracy mass spectromet...

A fluorescent colorimetric pH sensor was developed by a polymerization of a monomeric fluorescein based green emitter (SM1) with a monomeric 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran derived red emitter (SM2) in poly(2-hydroxyethyl methacrylate)-co-polyacrylamide (PHEMA-co-PAM) matrices. Polymerized SM1 (PSM1) in the polymer matrices showed bright emissions at basic conditions...

Omeprazole, a proton-pump inhibitor used in peptic ulcers, gastro-esophageal-reflux disorder, Zollinger-Ellison syndrome and in H. pylori infections. The omeprazole is unstable at acidic pH, undergoes degradation in stomach. To prevent the degradation in stomach, dosage forms are supplied as enteric-coated tablets or granules encapsulated in gelatin capsules. The efficiency of such dosage forms...

Safe biodegradable “green” alternatives with minimal environmental and health risks have received widespread research interest. Thirty different kinds of bio-based flocculants (modified starches, modified celluloses, native chitosan, and lignin-based flocculant) were pre-tested using a simple jar test for the examination of the applicability of new organic flocculants in papermaking and in cond...

Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into...

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