نتایج جستجو برای: polyamide composite

تعداد نتایج: 124362  

1997
Sarah White Eldon E. Baird Peter B. Dervan

In order to determine whether there is an orientation preference of pyrrole-imidazole (Py-Im) polyamide dimers with respect to the 5′-3′ direction of the backbone in the DNA helix, equilibrium association constants (Ka) were determined for a series of six-ring hairpin polyamides which differ with respect to substitution at the N and C termini. Affinity cleaving experiments using hairpin polyami...

Journal: :Mechanical Engineering Journal 2023

In this study, we will report the efficiency of hybrid filler for mechanical properties and thermal conductivity Polyamide-6 (PA6) composite. One ways to improve composite is add fillers matrix, but excessive causes form aggregation void. They make decline. As solution problem, use expected realize lower content with keeping properties. However, most efficient ratio unclear. PA6 were composited...

Journal: :Journal of composites science 2022

Composite materials are becoming widely applied in fire-critical conditions such as, e.g., aviation interior parts. Environmental considerations motivate the use of additive manufacturing due to decrease polymer wastes, and therefore additional fuel sources. The aim this work was evaluate effect printing direction on flame retardancy tensile properties 3D-printed test samples polyamide 12 manuf...

Journal: :Chemical communications 2009
Helen Willcock Andrew I Cooper Dave J Adams Steve P Rannard

Remarkable changes of properties result from systematically varying the surface functionality of polyamide dendrimers within a single generation.

Journal: :Journal of physics 2023

Abstract The flame-retardancy of enamelled wires was studied by using a cone calorimeter. characteristic parameters including time to ignition, heat release rate, total smoke and so on, were obtained. effect radiation flux on the flame retardancy analyzed. results show that is related content different components in composite insulation layer. Polyimide have good retardant performance, followed...

2014

Disclosed is an inhibitor of the expression of CTGF gene, which comprises a pyrrole-imidazole polyamide. The pyrrole-imidazole polyamide has an N-methylpyrrole unit (hereinafter, referred to as “Py”), an N-methylimidazole unit (hereinafter, referred to as “Im”) and a ϝ-aminobutanoic acid unit. In the pyrrole-imidazole polyamide, the region of the ϝ-aminobutanoic acid unit is folded to form an U...

Journal: :Bioorganic & medicinal chemistry 2014
Jevgenij A Raskatov James W Puckett Peter B Dervan

In an effort to quantitate Py-Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1-3, and investigated their tumor localization in a subcutaneous xenograft model of prostate cancer (LNCaP). Tumor concentrations were compared with representative host tissues, and exhibited a certain degree of preferential localization to the xenograft. Compound accumulat...

2008
Philippe Simon Fabio Cannata Loïc Perrouault Ludovic Halby Jean-Paul Concordet Alexandre Boutorine Vladimir Ryabinin Alexandre Sinyakov Carine Giovannangeli

The design of molecules that damage a selected DNA sequence provides a formidable opportunity for basic and applied biology. For example, such molecules offer new prospects for controlled manipulation of the genome. The conjugation of DNA-code reading molecules such as polyamides to reagents that induce DNA damages provides an approach to reach this goal. In this work, we showed that a bipyridi...

2014
Daisuke Obinata Akiko Ito Kyoko Fujiwara Ken-Ichi Takayama Daisaku Ashikari Yasutaka Murata Kenya Yamaguchi Tomohiko Urano Tetsuya Fujimura Noboru Fukuda Masayoshi Soma Takayoshi Watanabe Hiroki Nagase Satoshi Inoue Satoru Takahashi

Aberrant overexpression of ERG induced by the TMPRSS2-ERG gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole-imidazole (PI) polyamides recognize and attach to the minor groove of DNA with high affinity and specificity. In the present study, we designed a PI polyamide targeting TMPRSS2-ERG translocation breakpoints and assessed its effect on human prostate ca...

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