Molecular genetic testing is a reliable method for the definitive diagnosis of polycythemia vera (PV). The use interferon preparations in addition to hydroxyurea and antiplatelet agents could be associated with better therapeutic outcomes. In this report, we present clinical case young patient asymptomatic PV demonstrate effectiveness molecular analysis diagnosis.

Meliza Goi Roscani, Silmeia G. Zanati, Pericles S. Salmazo, Fabio C. Carvalho, Claudia G. Magalhães, Vera Therezinha M. Borges, Beatriz B. Matsubara, João C. Hueb I São Carlos Federal University (UFSCar) Department of Medicine, Internal Medicine, São Carlos/SP, Brazil. II Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Faculdade de Medicina de Botucatu, Internal Medicine, Botuca...

T HE APPARENTLY HIGH FREQUENCY of polycythemia vera among Jews has been first systematically approached by Reznikoff et al.’ and subsequently confirmed by Damon and Holub2 and by one of us.3 It seemed therefore of interest to find out whether this excessive risk is present in Jews outside the U.S.A. and among all Jewish ethnic subgroups. The following report provides an attempt to answer both q...

Polycythemia vera is a myeloproliferative neoplasm that can cause opposite complications: thrombosis and bleeding. Since arterial or venous often fatal, prevention of thrombogenesis the main treatment measure for polycythemia vera, both in daily life perioperatively. However, reports bleeding are less frequent than thrombosis. Herein, we report case which significant postoperative was periopera...

JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage. Initial hematologic data of these patients differ from those of V617F-positive patients, but there is no difference in thrombotic development and myelofibrotic transformation.

Polycythemia vera (PV) is a chronic myeloproliferative disease that is often complicated with thromboembolism. However, aortic stenosis (AS) could be a manifestation of the cardiovascular complications of PV possibly through shear stress and atherosclerosis. We report a rare case of rapidly progressed AS in a patient with PV.

Subarachnoid Hemorrhage and Diplopia as Initial Presentation of Polycythemia vera Christian Opherk a , Roland Brüning b , Hannah L. Pellkofer a , Martin Dichgans a , Gerhard F. Hamann a Departments of a Neurology and b Neuroradiology at the Institute of Clinical Radiology, Ludwig Maximilians University, Munich , Germany PV initially presenting with subarachnoid hemorrhage, in which a concomitan...

An oncolytic parasite to treat polycythemia vera I n recent years, there has been a surge of clinical trials to treat various kinds of cancers with non-replicating versions of viruses (1). The most famous among these is the recent use of a genetically engineered poliovirus used to treat one of the most difficult-to-treat and recurring cancers Á Glioblastoma Multiforme (2, 3). In addition, vario...

and inflammatory conditions including immune-mediated bone marrow failure and the often-profound pancytopenia seen in those patients treated with interferons. Apparently , IFN-␣ and IFN-␥ have similar effects in this Irgm1 pathway (Margaret Goodell, personal communication, June 2011). These observations have immediate clinical consequences as an easier-to-tolerate pegy-lated form of IFN-␣ has b...