Heparin proteoglycan formed by incubation of purified rat peritoneal mast cells with [3KS]sulfate has previously been shown to be a proteoglycan with an approximate average molecular weight of 750,000 by gel filtration. This proteoglycan which was isolated in the absence of proteases has now been shown to contain approximately equal amounts of serine and glycine which together account for 82% o...

A series of well-defined copolymer brushes, PS-g-P3HT, composed of a hydrophobic coil-like PS backbone and densely grafted rod-like P3HT side chains were successfully synthesized by a combination of the quasiliving Grignard metathesis (GRIM) method, reversible addition–fragmentation chain transfer (RAFT), and click reaction. The molecular weight distribution of the resulting PS-g-P3HT copolymer...

In this work, solid polymer nanospheres with their surface tailored for drug adhesion were prepared using a V-shaped microfluidic junction. The biocompatible polymer solutions were infused using two channels of the microfluidic junction which was also simultaneously fed with a volatile liquid, perfluorohexane using the other channel. The mechanism by which the nanospheres are generated is expla...

The initial response to treatment and subsequent development of resistance to carboplatin are very important challenges. Use of nano drug delivery is a new method to replace standard chemotherapy. In this research, both non-PEGylated and PEGylated nanoparticles (NPs) were prepared by mini-emulsion polymerization of poly (butyl cyanoacrylate) (PBCA) NPs. Characteristics such as size, polydispers...

Synthesis of random biscoumarin copolyester bearing pendant 3-(trifluoromethyl)styrene was prepared by the reaction of biscoumarin monomer 3 and hydroquinone 5 with azeloyl chloride. The influence of pendant 3-(trifluoromethyl)styrene unit on the properties of copolyester such as inherent viscosity, solubility, and thermal stability was investigated and compared in detail. The inherent viscosit...

This paper describes formulation considerations and in vitro evaluation of an oleic acid-based polyelectrolytic polymer-containing microemulsion drug delivery system designed for intranasal administration of a hydrophobic model drug Olanzapine. Drug-loaded microemulsions were successfully prepared by a water titration method. The microemulsion containing 4% oleic acid, 30% surfactant mixture of...

The preparation and technological characterization of nanosphere formulations (NS) containing the anticancer drug paclitaxel (PTX) are reported. Poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) nanospheres (NS) were prepared by a solvent displacement method. They showed a mean particle size in the range 150-300 nm, with a high homogeneity (polydispersity index < 0.3). For long term sta...

Biological effects of rutin bioactive are limited due to its poor oral bioavailability and its degradation in aqueous environments. For the purpose of bioenhancement, different nanoemulsion systems of rutin were developed by aqueous titration method using water as dispersion media. The nanoemulsion systems were characterized for surface morphology, droplet size, polydispersity index, zeta poten...

The paper explored the catalytic activity of a cell debris self-immobilized thermophilic lipase for polyester synthesis, using the ring-opening polymerization of ε-caprolactone as model. Effects of biocatalyst concentration, temperature, and reaction medium on monomer conversion and product molecular weight were systematically evaluated. The biocatalyst displayed high catalytic activity at high...

This paper discusses about preparation of biodegradable polymer /clay nanocomposites based on organically modified montmorillonite clay; i.e. cloisite 10A and biodegradable polymer chitosan by solution mixing technique and their characterization. The nanocomposites were successfully prepared and their structures were characterized by powder x-ray diffraction (XRD), particle size analyzer (Beckm...