We have recently described human hemoglobin surfacemodified with polyethylene glycol (MP4, registered trademark Hemospan) that does not possess the vasoconstrictive properties which have hampered development of some hemoglobin-based oxygen carriers. Based on in vitro studies, we postulated that this lack of vasoconstriction is due to decreased diffusive oxygen transfer in the plasma space as a ...

Multiple studies have shown that the progression of breast cancer depends on multiple signaling pathways, suggesting therapies with multitargeted anticancer agents will offer improved therapeutic benefits through synergistic effects in inhibiting growth. Dual-targeted inhibitors phosphoinositide 3-kinase (PI3-K) and histone deacetylase (HDAC) emerged as promising therapy candidates. However, po...

Nano-sized γ-Al2O3 was synthesized successfully by a simple method using Al2(SO4)3·18H2O as aluminium source and in the presence of polyethylene glycol (PEG 2000). FTIR spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscope (TEM) were used to characterize the structure and morphology of synthesized powder. The results showed that PEG playe...