In order to address preserved protein bioactivities and protein sustained-release problems, a method for preparing double-walled microspheres with a core (protein-loaded nanoparticles with a polymer-suspended granule system-formed core) and a second shell (a polymer-formed shell) for controlled drug release and preserved protein bioactivities has been developed using (solid-in-oil phase-in-hydr...

The objectives of this study were to fabricate cefixime-loaded chitosan microspheres with the ultimate goal of prolonging drug release and to analyze the influence of various process variables on the properties of microspheres such as mode of drug release. The cefixime-loaded chitosan microspheres were fabricated using a coacervation technique. Various process variables like volume of solvent f...

OBJECTIVES The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. MATERIALS AND METHODS Microspheres were prepared by water-in-oil-in-oil (W/O1/O2) emulsion-solvent diffusion (ESD). A mixed solvent system consisting of acetonitrile and dichloromethane ...

Previously microspheres containing metformin hydrochloride were prepared by using two different methods viz. ionotropic gelation and solvent evaporation method. In this study, acute toxicity studies were investigated in male albino rats following oral administration of the microspheres. The rats were carefully observed for any clinical signs for seven days, and gross observations of the organs ...

Poly(epsilon-caprolactone)-poly(ethylene glycol) (PECL) copolymers were synthesized from polyethylene glycol (PEG) and epsilon-caprolactone (epsilon-CL) using stannous octoate as catalyst at 160 degrees C by bulk polymerization. The effect of the molecular weight of PEG and the copolymer ratio on the properties of the copolymers was investigated by (1)H-NMR, IR, DSC and GPC. PCL and PECL micros...

Aim: In the present study, the main objective was to develop a multiparticulate system containing chitosan microspheres for colon-specific drug delivery of capecitabine for the treatment of colorectal cancer. Materials and Methods: This study was based on the microbial degradability of chitosan microspheres. The microspheres were prepared with chitosan by emulsion cross linking method. A factor...

A mass-based label-free detection of blood biomarkers under physiological conditions is realised using gold-plated magnetic polymer microspheres covered with self-assembled monolayers of polyethylene glycol alkanethiolates that effectively prevent heavy nonspecific binding of serum proteins.

Article history: Received on: 30/08/2013 Revised on: 03/10/2013 Accepted on: 15/10/2013 Available online: 31/10/2013 Azathioprine loaded gelatin microspheres were formulated to control/target drug release in an arthritic joint by magnetic force or intra-articular injection. Glutaraldehyde cross linked microspheres were characterized for drug loading, entrapment efficiency, gas chromatography, m...

Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we...

In the present study, gelatin microspheres containing ofloxacin were prepared by coacervation phase separation method and characterized by optical microscopy and scanning electron microscopy. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and In-vitro release pattern. The effect of process variables on microsphere size was studied and based on t...