McCune-Albright syndrome (MAS) is a rare, heterogenous, clinical condition caused by a rare genetic mutation. The disorder is more common in females and is characterized by a triad of cutaneous, bone and endocrine abnormalities.  We describe a girl patient with MAS having precocious puberty and multiple cafe-au-lait macules and deforming polyostotic fibrous dysplasia of bone. Clinical presentat...

Fibrous dysplasia (FD) is a developmental anomaly in which the normal bone marrow replaced by fibro-osseous tissue. can affect either single (monostotic) or multiple (polyostotic) bones. Craniofacial FD monostotic involving craniofacial However, CFD one of rare forms FD. Aneurysmal cyst (ABC) non-neoplastic lesion. ABCs are expansile lytic lesions composed numerous blood-filled channels and cys...

Fibrous dysplasia is a benign bone disease first described by Lichtenstein in 1938. It is characterized by progressive replacement of normal bone with fibro-osseous connective tissue. When the disease involves craniofacial skeleton, it results in significant disfigurement and other functional problems. This paper reports a case of large craniofacial fibrous dysplasia involving zygomaticomaxilla...

Paget's disease of bone (PDB) is a very rare disease in the Asian countries including Japan, although as a bone metabolism disease it is relatively common in Europeans and Americans. An infrequent complication of PDB is the giant cell tumor (GCT). We encountered a case of GCT in the maxilla complicating PDB in a 57-year-old Japanese woman. She developed her first GCT in the right occipital bone...

A 6-month-old female neutered domestic shorthair cat was examined for pain and swelling of the distal limbs. Swelling and malalignment of both carpi, dorsiflexion of the distal metatarsals and a mild, multicentric lymphadenopathy were detected on examination. Screening blood tests revealed a biclonal gammopathy, hypercalcemia and atypical leukocytes. Survey radiographs revealed lysis and prolif...

McCune-Albright syndrome (MAS) is characterized by the triad of precocious puberty, café au lait pigmentation, and polyostotic fibrous dysplasia (FD) of bone, and is caused by post-zygotic somatic mutations-R201H or R201C-in the guanine nucleotide binding protein, alpha stimulating (GNAS) gene. In the present study, a novel peptide nucleic acid (PNA) probe with fluorescent labeling was designed...