Measurement of 6 -aminolevulinic acid synthetase (ALA-S) activity in human plasma has been carried out with samples from normal individuals, cases of erythropoietic porphyria (EP) and erythropoietic protoporphyria (EPP), and of the three principal forms of hepatic porphyria-acute intermittent porphyria, variegate porphyria, and porphyria cutanea tarda. The method of measurement depends on forma...

One of the three pathways for the metabolisation of dietary tryptophan is the formation of serotonin. Tryptophan hydroxylase catalyses the formation of 5-hydroxytryptophan, the first and regulatory step of this biosynthesis. The aim of the present work is to study alterations in this tryptophan metabolism in rats with experimental Porphyria Cutanea Tarda induced by hexachlorobenzene. With this ...

BACKGROUND Antidepressant prescribing rates in England have been increasing since the 1970s. The impact of the Improving Access to Psychological Therapies (IAPT) initiative on antidepressant prescribing rates is unknown. AIM To investigate the impact of the establishment of IAPT services on antidepressant prescribing rates in primary care trusts (PCTs) in England. DESIGN AND SETTING A longi...

Graham Williamson asserts the right to be identified as the author of this work in accordance with sections 77 and 78 of the Copyright, Designs and Patents Act 1988. Sedgefield PCT Speech and Language Therapy Department cannot be held responsible for errors or for any consequences arising from the use of the information contained in this article. Any part of this publication may be freely repro...

Graham Williamson asserts the right to be identified as the author of this work in accordance with sections 77 and 78 of the Copyright, Designs and Patents Act 1988. Sedgefield PCT Speech and Language Therapy Department cannot be held responsible for errors or for any consequences arising from the use of the information contained in this article. Any part of this publication may be freely repro...