In this paper, we propose an extension of the vehicle routing problem with crossdocking that takes into account resource constraints at the cross-dock. These constraints limit the number of docks that can be used simultaneously. To solve this new problem, we adapt a recently proposed matheuristic based on large neighborhood search. In particular, we focus on the feasibility tests for insertions...

Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...

This paper describes the synthesis and application of alginate-chitosan-cyclodextrin micro- and nanoparticulate systems loaded with isoniazid (INH) and isoconazole nitrate (ISN) as antimycobacterial compounds. Preparation and morphology of the obtained particles, as well as antimycobacterial activity data of the obtained systems are presented. Docking of isoconazole into the active site of enoy...

We examine the distribution and interpretation of post-copular noun phrases in French when they appear with and without an indefinite article (Marie est (une) physicienne). We propose that the alternation is due to the fact that the indefinite article marks saturation of an NP-internal argument slot, and show that because of this, post-copular indefinite NPs are usually but not always existenti...

Six DOF offset sensing between two plates is important for automatic docking mechanisms. This paper presents an easy and inexpensive implementation of such a system using four commercial-off-the-shelf (COTS) infrared (IR) light emitting diode (LED) emitters and two COTS IR receivers on each of two docking plates. The angular intensity distribution of an emitter and the sensitivity distribution ...

Based on Buyback agreement of Stackelberg Game, this article analyzed the impact of sharing buyback cost for optimal production and different choices of supermarkets and farmer professional cooperatives in distribution model and direct model for agricultural-super docking supply chain in china. At the same time, this article designed a buyback agreement model and explores the nature of buyback ...

Axtell, Axelrod, Epstein and Cohen (1996) describe a docking or alignment process and experiment for verifying simulations. By comparing simulations built independently using different simulation tools, the docking or alignment process may discover bugs, misinterpretation of model specification, and inherent differences in toolkit implementations. If the behavior of the multiple simulations are...

background: different postdesigns and materials are available; however, no consensus exists regarding superiority for stress distribution. the aim of this study was to evaluate the effect of design and material of post with or without ferrule on stress distribution using finite element analysis. materials and methods: a total of 12 three‑dimensional (3d) axisymmetric models of postretained cent...

Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...

In this work, a comparative study about the incorporation of silver nanoparticles (AgNPs) into thin films is presented using two alternative methods, the in situ synthesis process and the layer-by-layer embedding deposition technique. The influence of several parameters such as color of the films, thickness evolution, thermal post-treatment, or distribution of the AgNPs along the coatings has b...