The efficacy of drug delivery to the posterior segment by systemic, local or topical routes is hindered by the blood-retinal barrier, tight intercellular junctions and scantly vascularized spaces. Although intravitreal injection has proved effective for delivery of therapeutic agents into the vitreous cavity and retina, it is impractical for frequent or sustained dosing. Intravitreal sustained ...

After making a map of response properties of neurons in a roughly 3 X 4 mm region of area 18 in the cat, we injected wheat-germ agglutinin horseradish peroxidase (WGA-HRP) and succinylated concanavalin A (Con A) into physiologically identified regions of the map. We observed up to 10 patches of retrogradely labeled cells surrounding each injection site. The majority of the patches occurred with...

This study tests the hypothesis that high-density particle-stabilized emulsion droplets (PEDs) can be designed to use gravity to target specific locations in the eye via suprachoroidal space injection. PEDs contain a core of high-density perfluorodecalin measuring ≤35 μm in diameter surrounded and stabilized by fluorescein-tagged, polystyrene nanoparticles that simulate polymeric drug carriers....

PURPOSE To determine the diagnostic effect of prostaglandin E(1) on contrast enhancement quality of CT during arterial portography (CTAP). MATERIALS AND METHODS Our patients population included 30 patients (11 women, 19 men; age range, 41 approximately 81 years) with liver tumors (23 hepatocellular carcinoma and 7 metastatic liver tumor) who had undergone angiography. We divided the 30 patien...

OBJECTIVES/HYPOTHESIS To investigate the efficacy of paclitaxel, a potent microtubule inhibitor with a more favorable therapeutic index as compared with vincristine, in preventing post-traumatic nerve regeneration of the recurrent laryngeal nerve into the posterior cricoarytenoid muscle in a canine laryngeal model. STUDY DESIGN Experimental animal study. METHODS Forty-nine canine hemilaryng...

Purpose. This study aims to evaluate the regression of retinopathy of prematurity (ROP) after one intravitreal injection of bevacizumab and the factors that influenced it. Methods. This retrospective case series was carried out at the "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. It includes all the consecutive infants treated for ROP with one intravitreal bevaciz...

Objective The purpose of the study is to report and to analyze the complications following intratympanic injections (ITI) of steroids. The occurrence rate of complications at different ITI sites, four quadrants of eardrum, was also compared. Methods A retrospective clinical review in a medical center. Each patient received ITI twice in a week for 2-3 consecutive weeks as a salvage therapy for...

BACKGROUND Joint injections and aspirations are used to reduce joint pain and decrease inflammation. The efficacy of these injections is diminished when they are placed inadvertently in the wrong location or compartment. The purpose of this study was to determine whether the use of varying sites or imaging techniques affects the rate of accurate needle placement in aspiration and injection in t...

A pars plana injection of Viscoat (sodium hyaluronate 3%-chondroitin sulfate 4%) was used to stabilize and elevate a descending nucleus in 8 patients with posterior capsule rupture. The nucleus or nuclear remnants were successfully removed in all 8 patients.