1) To the comment of the referee: Abstract: in the conclusion paragraph of the abstract, the authors reported they found a trend for emesis. However, they did not specify the drug for which the trend was observed. Please, specify, the authors replied: This has been clarified. However, in the sentence There was a trend toward less emesis in the >0-72 h time period the drug for which the trend wa...

Postoperative nausea and vomiting continue to be problematic areas in anesthesia as evidenced by frequent reports of therapies in the literature. No single therapy has been proven curative for all cases, in part because of the several emetic centers, all of which may be blocked by different classes of drugs and the diverse risk factors which act alone or in combination to cause vomiting. Identi...

Despite major advances, emesis remains a major problem in the context of cancer chemotherapy and in the postoperative period. A better understanding of the relevant neurocircuitry, especially the central pattern generator responsible for emesis and the central role of substance P, led to the development of a new class of antiemetics: the neurokinin-1 (NK1) receptor antagonists. Aprepitant is th...

BACKGROUND Postoperative nausea and vomiting is one of the most common side effects associated with surgical procedures. OBJECTIVES The aim of this study was to determine the effect of ginger on intensity of nausea and vomiting after surgical procedures. PATIENTS AND METHODS This study was a randomized, double blinded, clinical trial. 160 eligible patients were randomly assigned into experi...

BACKGROUND Palonosetron is a new potent 5-hydroxytryptamine 3 antagonist. Although this drug is thought to be more effective in patients receiving opioid-based patient-controlled analgesia (PCA), clinical data are lacking. This study compared the effects of i.v. ondansetron and palonosetron administered at the end of surgery in preventing postoperative nausea and vomiting (PONV) in high-risk pa...