We studied and performed genetic linkage studies and mutational analysis on 1 1 patients from 5 unrelated kindreds with Andersen's syndrome (AS). Our data suggest AS is a distinct periodic paralysis occurring in the setting of either hyperor hypokalemia, with severe cardiac involvement (LQT) and distinct skeletal abnormalities whose gene defect is still unknown.

The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that is often associated with lung cancer which shares a common antigenic protein with the motor nerve terminal. The myasthenic weakness is caused by an antibody-induced reduction in the release of acetylcholine from the nerve terminal. This study was undertaken to determine the target of LEMS antibodies and specify the volta...

of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase C. Neuropsychopharmacology 2012; 37: 543–56. Parkinson Study GroupPhase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson’s disease (STEADY-PD). Mov Disord 2013; 28: 1823–31. Puopolo M, Binshtok AM, Yao GL, Oh SB, Woolf CJ, Bean BP. P...