The typically planar amide when incorporated into bicyclic systems can undergo a significant distortion from planarity resulting in physical properties and reactivity that deviate from classical amide behaviour. Herein, we report a succinct protocol that utilises potassium permanganate to selectively α-oxygenate the benzylic position of ethano-Tröger's base derivatives to yield a new class of t...

A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with an O-tosyloxazoline derivative, followed by an oxazoline ring-opening reaction and oxidation of the N-protected β‑aminoalcohol by potassi...

A convenient approach for oxidation of structurally diverse alcohols has been developed using KMnO4 as oxidant agent in the presence of a catalytic amount of Al2O3 in aqueous acetonitrile. In this method various alcohols generally afforded the corresponding carbonyl compounds directly in good to high yield under ultrasound irradiation conditions. It shows that this kind of catalysis system is v...

The publications on Kjeldahl’s method for determining nitrogen that have appeared since Kjeldahl’s (1) original paper in 1883 perhaps outnumber those on any other analytical method in the same period of time.1 The diversity of papers is attributable to the immense usefulness of the method, to its need for modifications for applications to various types of organic and inorganic compounds, and to...

Pesticides are used as the main tool for agricultural pest control. Many pesticides are, however, toxic substances and persistent in character. Concern over the pesticide residues in fruits and vegetables have led to the development of many clean up and analysis methods. Biosurfactant was used in this study to explore the possible potential for cleaning up cypermethrin residue. Lettuce was chos...

A new simple and sensitive kinetic spectrophotometric method for the determination of silymarin in pure form and in pharmaceutical formulations is described. The method is based on the oxidation of the drug with potassium permanganate at pH 7.0 +/- 0.2. The reaction is followed spectrophotometrically by measuring the decrease in the absorbance at 530 nm. The calibration graph is linear in the r...

The demonstration of the marked biological activity of oxybiotin (l-4), the oxygen analogue of biotin, has focused attention upon the mode of action of this compound. It became of particular interest to determine whether oxybiotin possesses intrinsic activity or whether its biological potency is due to its conversion into biotin. The evidence in the literature is conflicting on this point. Hofm...