OBJECTIVES Acetaminophen (APAP) toxicity is known to be common and potentially fatal. This study aims to investigate the protective effects of hydroalcoholic extract, remaining from Crocus sativus petals (CSP) against APAP-induced hepatotoxicity by measuring the blood parameters and studying the histopathology of liver in male rats. MATERIALS AND METHODS Wister rats (24) were randomly assigne...

A complementary DNA (cDNA) for rat hepatic aryl sulfotransferase IV (AST IV) was isolated, characterized, and used as a hybridization probe to evaluate the molecular basis for the differential expression of AST IV during 2-acetylaminofluorine (2AAF)-induced hepatocarcinogensis. The AST IV cDNA clone was obtained by immunochemical screening of a male Sprague-Dawley rat liver cDNA library. The AS...

6 Author Contributions: The authors contributed to the manuscript by their involvement in: 7 Conception and design of research: AST, AA 8 Performed experiments: AST, AA 9 Analyzed data: AST, AA, MKJ 10 Interpreted results of experiments: AST, AA, MKJ 11 Prepared figures: AA, AST 12 Drafted manuscript: AA, AST 13 Edited and revised manuscript: AST, AA, MKJ 14 Approved final version of manuscript...

A pseudo-solenoid is a compact connected metrizable space that an inverse limit of circles and has characteristic feature, called hereditary indecomposability. The class pseudo-solenoids topological rigidity in two $X$

Alaska Simulator Toolset (AST) is a software suite developed at the University of Innsbruck for exploring different approaches to business process flexibility by using a familiar metaphor, i.e., travel planning and execution. For this, AST provides integrated support of several decision deferral based approaches to process flexibility and enables their systematic comparison. Moreover, AST facil...

Enzymatic sulfation of A'-hydroxylated arylamines by mammalian hepatic cytosol sulfotransferases (AST; EC 2.8.2.1) is an important metabolic step which generates ultimate carcinogens. The metabolic activity of AST IV, the putative ¡sozymicform of AST primarily respon sible for catalyzing /V-hydroxy-2-acetylaminofIuorene sulfation, is mod ulated during 2-acetylaminofluorene (AAF)-induced rat he...

In vitro supplementation with the active form of vitamin B6, pyridoxal-phosphate (PLP), increases measurements of both serum aminotransferase enzymes, L-aspartate: 2-oxoglutarate amino transferase, EC 2.6.1.1 (AST) and L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2 (ALT). The plasma PLP level in normal individuals clearly relates inversely to the degree of stimulation of serum AST and A...