We study a problem faced by a major beverage producer. The company produces and distributes several brands to various customers from its regional distributors. For some of these brands, most customers do not have enough demand to justify full pallet shipments. Therefore, the company decided to design a number of mixed or “rainbow” pallets so that its customers can order these unpopular brands w...

Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Triphala (Terminalia chebula, Terminalia belerica, and Emblica officinalis) on total cholesterol, Low density lipoprotein (LDL), Very low density lipoprotein (VLDL), High density lipoprotein (HDL) and free fatty acid in experimentally induced hyper...

Preformulation studies regarding a physico-chemical evaluation of memantine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, are presented in this work. This characterization of memantine is pre-required for the formulation of a parenteral solution. The water solubility, the thermal behavior and the chemical stability in aqueous solution, depending on the pH, temperature, UV ...

A simple in vitro method for the detection of precipitation using 96-well microplates and a SpectraMax Plus microtiter plate reader has been developed and described. The method requires only small amount of drug and is, therefore, potentially applicable in early pre-formulation. The method is based on opacity changes that occur with precipitation and yields several descriptive parameters, onset...

As technological advances allow us to fabricate smaller autonomous self-propelled devices, it is clear that at some point directed propulsion could not come from pre-specified deterministic periodic deformation of the swimmer's body and we need to develop strategies for extracting a net directed motion from a series of random transitions in the conformation space of the swimmer. We present a th...

In this chapter we start by developing the analytical formulation of a general structure for the nonlinear distortion. This formulation, based on the Volterra series expansion, is provided in order to demonstrate the validity of some classical approximations concerning the use of higher order nonlinear models for HPA characterization. Then, one of the most validated HPA models is described in s...

Here we provide an extremely simple, rapid, direct, sensitive and specific HPLC method to quantify moxifloxacin in rabbit aqueous humor. Separation of moxifloxacin was performed on a Kromasil C8 column using a ternary pre-mixed mobile phase of acetonitrile, methanol and 0.02 M KH2PO4 buffer solution containing 1% triethylamine (pH 3.0 with phosphoric acid) (15:20:65, v/v/v). UV detection at 292...

Present study was undertaken to assess the potential of Glycerosomes as a novel drug delivery system for topical application of Minoxidil. Pre-formulation studies were done for identification of drug as well as for determination of its physiochemical properties. Spectra of various mixtures of drug and excipients do not show any additional peak thus, indicating compatibility with each other. Gly...

Cisplatin-loaded protransfersome system was prepared and characterized for in vitro drug permeation, drug deposition and antitumor effect. A histopathological study and a genotoxicity study were also done. The skin permeation data of cisplatin from protransfersome gel formulation revealed 494.33 ± 11.87 μg cm-2, which was significantly higher than that from the control plain drug solution in 0....

We present a new algorithm to register 3D pre-operative Magnetic Resonance (MR) images with intra-operative MR images of the brain. This algorithm relies on a robust estimation of the deformation from a sparse set of measured displacements. We propose a new framework to compute iteratively the displacement field starting from an approximation formulation (minimizing the sum of a regularization ...