A study of 318 patients with tubal infertility and a control group of 200 unselected infertile women yielded 14 (4.4%) and 1 (0.5%), respectively, with precancerous lesions of the cervix uteri. The one patient in the control group with severe dysplasia was later shown to have tubal infertility. The overall incidence of premalignant lesions of the cervix uteri as reported to the National Cancer ...

In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for t...

Proliferative glomerulonephritis (GN) with monoclonal immunoglobulin deposits (PGNMIDs) is a recently described entity among the spectrum of gammopathy renal significance (MGRS). The disease limited and manifests in chronic glomerular disease, altered function albuminuria, sometimes nephrotic range. Acute nephritic syndrome rare. Until recently, absence criteria for symptomatic haematological p...

Actinic cheilitis (AC) is a precancerous condition of the lip that primarily affects people with Fitzpatrick skin types I and II as a result of chronic exposure to solar irradiation. Additional factors include poor oral hygiene, chronic lip irritation, and excessive tobacco use. The clinical spectrum of AC is varied and may include erythema, leukoplakia, scaling, atrophy, dryness, fissures, ulc...

Background. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell growth, cell cycling, and tumour differentiation. Objective. The purpose of the study was to comp...

Ingenol is a diterpenoid with unique architecture and has derivatives possessing important anticancer activity, including the recently Food and Drug Administration-approved Picato, a first-in-class drug for the treatment of the precancerous skin condition actinic keratosis. Currently, that compound is sourced inefficiently from Euphorbia peplus. Here, we detail an efficient, highly stereocontro...

The Study was conducted to evaluate the prevalence of Use of tobacco & its associated products & Oral Sub Mucous Fibrosis among teenagers. It was conducted on 750 school going teenagers of Dehradun city. Results of the study showed that 34.1% of the study subjects used tobacco & its associated products & among them 14.2% of Oral Sub Mucous Fibrosis cases were identified. Association between typ...

Helicobacter pylori infection is associated with many gastroduodenal diseases such as peptic ulcer disease and gastric cancer (Uemura et al., 2001). The organism is the major cause of chronic active gastritis resulting in chronic atrophic gastritis and its end stage, gastric atrophy, which is believed to be a precancerous lesion (Pandey et al., 2010). Intestinal metaplasia, usually associated w...

Following very clear recommendations of the National Advisory Committee on Immunization, the Canadian government has earmarked $300 million for purchasing human papillomavirus (HPV) vaccine. I am in almost complete agreement with this decision. I might be seen as biased, as I was an investigator for the quadrivalent vaccine, but I am more biased owing to the fact that I have performed thousands...

Submit Manuscript | http://medcraveonline.com to chronic iron deficiency calling it as an Asian analogue of sideropenic dysphagia [3]. OSMF has been predominantly reported among Indians living in India as well as outside, to a lesser extent among other Asiatics and, sporadically, among Europeans. With a reported prevalence ranging up to 0.4% in Indian rural populations [4], several million indi...