This paper discusses the significance and interpretation of uncertainty in the remaining useful life (RUL) prediction of components used in several types of engineering applications, and answers certain fundamental questions such as “Why is the RUL prediction uncertain?”, “How to interpret the uncertainty in the RUL prediction?”, and “How to compute the uncertainty in the RUL prediction?”. Prog...

Experiments to identify the knock trends of lean gasoline-air mixtures, and such mixtures enhanced with hydrogen (H2) and carbon monoxide (CO), were performed on a single-cylinder research engine with boosting capability. The experimental method used to investigate knock trends consisted of determining the octane number (ON) of the primary reference fuel (mixture of isooctane and n-heptane) sup...

the ground improvement using plastic board drain (pbd) in soft soil was undertaken by sand mat formation, pbd installation, preloading surcharge, and removal of surcharge. during this procedure, the sand mat formation induced an initial settlement. however, it was very difficult to estimate that settlement due to pbd installation, which frequently destroyed the instruments installed in the grou...

background: municipal solid waste (msw) is the natural result of human activities. msw generation modeling is of prime im­portance in designing and programming municipal solid waste management system. this study tests the short-term pre­diction of waste generation by artificial neural network (ann) and principal component-regression analysis. methods: two forecasting techniques are presented in...

Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...

The physiological consequences of aberrant Ca(2+) binding and exchange with cardiac myofilaments are not clearly understood. In order to examine the effect of decreasing Ca(2+) sensitivity of cTnC on cardiac function, we generated knock-in mice carrying a D73N mutation (not known to be associated with heart disease in human patients) in cTnC. The D73N mutation was engineered into the regulatory...

Ethanol's action on the brain likely reflects altered function of key ion channels such as glutamatergic N-methyl-D-aspartate receptors (NMDARs). In this study, we determined how expression of a mutant GluN1 subunit (F639A) that reduces ethanol inhibition of NMDARs affects ethanol-induced behaviors in mice. Mice homozygous for the F639A allele died prematurely while heterozygous knock-in mice g...

Although modulation of protein levels is an important tool for study of protein function, it is difficult or impossible to knockdown or knockout genes that are critical for cell growth or viability. For such genes, a conditional knockdown approach would be valuable. The FKBP protein-based destabilization domain (DD)-tagging approach, which confers instability to the tagged protein in the absenc...