background: high cesarean section rate is a major health problem in developing countries. this study was established to evaluate the effectiveness of iranian ministry of health and medical education protocols on cesarean section rate trend. methods: through a non-concurrent controlled quasi-experimental study, cesarean section rate in shohada-e-tajrish and taleghani hospitals in tehran was comp...

The optimal management of preterm premature rupture of membranes (PROM) is controversial. Maternal risks must be weighed against fetal benefit when expectant management is considered. Despite concerns about maternal harm, protocols of expectant management seem to afford the best perinatal outcomes. Given that infection often is the common pathway for delivery in preterm PROM, recent reports hav...

OBJECTIVE To determine the risk of recurrent spontaneous preterm birth (sPTB) following sPTB in singleton pregnancies. DESIGN Systematic review and meta-analysis using random effects models. DATA SOURCES An electronic literature search was conducted in OVID Medline (1948-2017), Embase (1980-2017) and ClinicalTrials.gov (completed studies effective 2017), supplemented by hand-searching bibli...

Preterm birth (<37 weeks) complicates 12.5% of all deliveries in the USA, and remains the leading cause of perinatal mortality and morbidity, accounting for as many as 75% of perinatal deaths. Despite the recent temporal increase in preterm birth, efforts to understand the problem of prematurity have met with little success. This may be attributable to the under-appreciation of the etiologic he...

Background: Preterm premature rupture of membranes (PPROM) and preterm birth results in one third perinatal mortality maternal morbidity such as chorioamnionitis abruption placenta caesarean section, occurs 3% pregnancies. PPROM is associated with intrauterine infection. Early detection infection may help prevent neonatal sepsis. Objective present study was to analyse the outcome patients betwe...

Fetal membrane rupture is associated with increased expression of matrix metalloproteinase-9 (MMP-9) and matrix degradation. We have determined the functional significance of a variable number tandem repeat and a single nucleotide polymorphism (SNP) in the MMP-9 gene on promoter activity and their association with preterm premature rupture of membranes (PPROM). The 14 CA-repeat allele was a str...