In the Software/Hardware Engineering model-driven design methodology, the preservation of real-time system properties can be guaranteed up to a small time-deviation in the model synthesis. Therefore, this methodology is well suited for the design of control-systems in which execution times of actions are small; thus the time-deviations obtained are small. However, in systems containing time-int...

Digital preservation aims to keep digital objects accessible over long periods of time, ensuring the authenticity and integrity of these digital objects. In such complex environments, Risk Management is a key factor in assuring the normal behaviour of systems over time. Currently, the digital preservation arena commonly uses Risk Management concepts to assess repositories. In this paper, we int...

Supercooling preservation holds the potential to drastically extend the preservation time of organs, tissues and engineered tissue products, and fragile cell types that do not lend themselves well to cryopreservation or vitrification. Here, we investigate the effects of supercooling preservation (SCP at -4(o)C) on primary rat hepatocytes stored in cryovials and compare its success (high viabili...

After 1980s, the People’s Republic of China modernized rapidly, resulting in vast changes to the fabric of cities. At the same time, China developed more sophisticated urban planning practices and historic preservation regulation. In 1982, the government officially created the concept of “predominant historic and cultural city,” for cities that are considered to have very significant historic a...

The causes of transplant-associated coronary artery disease remain obscure, and there is no known treatment. Preservation injury of murine heterotopic vascularized cardiac isografts caused a small, albeit significant, increase in neointimal formation; preservation injury of allografts markedly increased both the incidence and severity of transplant-associated coronary artery disease. As cAMP is...

BACKGROUND Over the last 3 decades, we have seen a paradigm shift in our approach to the treatment of malignancy. During that time, organ conservation protocols have become standard in the treatment of breast cancer, laryngeal cancer, esophageal cancer, anal cancer and soft tissue sarcomas. METHODS Data from reports of bladder preservation protocols were reviewed to evaluate organ preservatio...

Structured Abstract: Purpose – Scalable decision support and business intelligence capabilities are required to effectively secure content over time. This article evaluates a new architecture for scalable decision making and control in preservation environments for its ability to address five key goals: (1) Scalable content profiling, (2) Monitoring of compliance, risks and opportunities, (3) E...

For a long time standard treatment approach for resectable squamous cell carcinoma of larynx was surgery with or without subsequent radiotherapy. Surgery, particulary total laryngectomy, has been associated with serious impairment of quallity of life. Between nonsurgical approaches, concurrent cisplatin based chemoradiotherapy has become a very promising treatment modality for larynx preservati...

RECENTL Y we reported that. in human liver transplantation, a preservation period of greater than 20 hours caused the rate of graft failure to increase nonlinearly.l Even with University of Wisconsin (UW) solution. there is a finite limit to the permissible time of cold storage of livers. In this study, we investigated whether microcirculatory disturbance during and after preservation is correl...

Digital preservation ensures continued access to digital information over time (e.g., 5, 15, 25 or 50 years). The long-term planning horizon of preserving relevant parts of a business processes raises a number of new research challenges for software design, development and maintenance (cf. [1]). In this paper we describe the challenges caused by the preservation of software and give a short ove...