© 2009 The Authors. doi: 10.2340/00015555-0644 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Bullous pemphigoid (BP) is the most frequent autoimmune bullous disorder. BP is associated with anti bodies to two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230 (1). The disorder usually affects elderly people, and severe pruritus is typically present. In the...

The clinical, biochemical and immunological features of 180 patients with hyperthyroid Graves' disease managed at the Universiti Kebangsaan Malaysia (UKM) Endocrine Clinic from 1983 to 1987 were examined. The prevalence of the disease is highest in Chinese and lowest in Indians. The female: male ratio is 2.8:1. Hypokalaemic periodic paralysis and hypercalcaemia were present in 5.0% and 1.7% of ...

Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squam...

167 A 44-year-old man was admitted to our hospital with complaints of weakness, arthralgia and fever for three weeks. He had a two-year history of hypertension and was a hepatitis B carrier for four years. His physical examination revealed hepatomegaly 4 cm below the costal margin, pretibial edema and maculopapular eruptions, especially on his legs and abdomen, reported to have been present for...

There have been few photographic studies done on lymphatics of human skin with previous images obtained by indirect dye injection into the dermis. We have developed a direct injection technique for investigating the lymphatic system in human adult cadavers and used this to investigate superficial lymphatics of the legs in a fresh human cadaver. We found an unusual observation in a skin graft sc...

INTRODUCTION Eosinophilic fasciitis is an uncommon disorder with unknown etiology and a poorly understood pathogenesis. We present the cases of two patients with eosinophilic fasciitis with unusual presentation, and describe the clinical characteristics and laboratory findings related to them. CASE PRESENTATION The first case involves a 29-year-old Turkish man admitted with pain, edema and in...

Introduction: Eosinophilic fasciitis (EF) is an uncommon disorder with unknown etiology and its pathogenesis is poorly understood. Case presentation: Herein, we present two cases of EF with unusual presentation and describe theirs clinical characteristics and laboratory findings. The first case was a 29year-old male admitted with pain, edema and induration of the right upper limb and left lower...

Preeclampsia is the most common hypertensive disorder to occur during pregnancy. A healthy 38-year-old primipara presented with pretibial edema at 33 weeks of gestation followed by the development of proteinuria at 36 weeks of gestation. She had no past medical history of hypertension and was normotensive during gestation. Her proteinuria persisted after delivery, and she was also hypoalbuminem...

A case of retroperitoneal fibrosis is described along with serological findings during the therapeutic course. An 81-year-old man with diabetes mellitus treated by insulin therapy was admitted because of bilateral pretibial edema. Abdominal computed tomography demonstrated tumorous lesions around the abdominal aorta and the hilum of the spleen. Open biopsy specimens showed excessive production ...

Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs. EN affects women more than men and can be idiopathic or secondary to another disease process such as infection or an immune response. Treatment options for erythema nodosum are suboptimal and often involve sig...