A number of environmental chemicals, by mimicking natural hormones, can disrupt endocrine function in experimental animals, wildlife, and humans. These chemicals, called "endocrine-disrupting chemicals" (EDCs), are such a scientific and public concern that screening and testing 58,000 chemicals for EDC activities is now statutorily mandated. Computational chemistry tools are important to biolog...

Are there sex differences in criteria for sexual relationships? The answer depends on what question a researcher asks. Data suggest that, whereas the sexes differ in whether they will enter short-term sexual relationships, they are more similar in what they prioritize in partners for such relationships. However, additional data and context of other findings and theory suggest different underlyi...

this paper aims at providing a new model based on data envelopment analysis (dea) to prioritize project risks. it is clear that the large amounts of involved capitals, the long term of infrastructure projects’ implementation, and the project management problems in on-time completion of projects indicate the necessity of paying particular attention to this issue and conducting applied research i...

An integrated health care system used an online database that captured pharmacists' reports of medication errors and an algorithm that helped classify and prioritize the information to identify patterns and improve safety outcomes.

Although Genome Wide Association Studies (GWAS) have identified many susceptibility loci for common diseases, they only explain a small portion of heritability. It is challenging to identify the remaining disease loci because their association signals are likely weak and difficult to identify among millions of candidates. One potentially useful direction to increase statistical power is to inco...

OBJECTIVE We demonstrate a genome-wide method for the integration of many studies of gene expression of phenotypically similar disease processes, a method of multiplex meta-analysis. We use immune dysfunction as an example disease process. DESIGN We use a heterogeneous collection of datasets across human and mice samples from a range of tissues and different forms of immunodeficiency. We deve...

OBJECTIVE Patients with comorbid chronic conditions may prioritize some conditions over others; however, our understanding of factors influencing those prioritizations is limited. In this study, we sought to identify and elaborate a range of factors that influence how and why patients with comorbid chronic conditions prioritize their conditions. METHODS We conducted semi-structured, one-on-on...