Chronic inflammation plays a key role in the development and progression of several chronic diseases. Inhibiting inflammatory cascade, thereby minimising damage caused by mediators, can be one strategies disease management. In addition, is closely related to apoptosis, cause apoptosis. Lemon peel has been reported have antioxidant anti-inflammatory biological activities. This study aimed invest...

Purpose: To determine the effect of bacoside-A on Parkinson's disease (PD) in a rat model, and elucidate its mechanism action.Methods: A model PD was established by administration 5 µL 6-hydroxydopamine ascorbic acid (0.1 %). Measurement serum levels inflammatory factors carried out using enzyme-linked immunosorbent assay (ELISA) kits. Western blotting used to Bax, cytochrome c Bcl-2 hippocampu...

Transforming growth factor (TGF)-β exhibits both pro-apoptotic and anti-apoptotic effects on epithelial cells in a context-dependent manner. The anti-apoptotic function of TGF-β is mediated by several downstream regulatory mechanisms, and has been implicated in the tumor-progressive phenotype of breast cancer cells. We conducted RNA sequencing of mouse mammary gland epithelial (NMuMG) cells and...

Procaspase-2 is one of the aspartate-specific cysteine proteases that are activated in response to various apoptotic stimuli. Two isoforms of human procaspase-2 have been described initially. Overexpression of the long isoform (caspase-2L) promotes cell death whereas the short isoform (caspase-2S) antagonizes some apoptotic pathways. In the present study, we identified two additional CASP-2 mRN...