objective: bone marrow mesenchymal stem cells reside in bone marrow and support homing and differentiation of hematopoietic stem cells (1). this makes them an excellent instrument for regenerative treatment and co-culture with the hsc. materials and methods: in this study, k562 cell lines were treated with butyric acid(for erythroid differentiation), co-cultured with mesenchymal stem cells and ...

Objective(s): Studies have confirmed that microgravity, as a mechanical factor, influences both differentiation and function of mesenchymal stem cells. Here we investigated the effects of simulated microgravity on neural differentiation of human adipose-derived stem cells (ADSCs). Materials and Methods:We have used a fast rotating clinostat (clinorotation) to simulate microgravity condition. R...

  Objective(s): Erythropoiesis is regulated by some extrinsic and intrinsic factors as microRNAs (miRNAs). miRNAs are endogenously small non-coding regulatory RNAs which play vital roles in the variety of cellular fate, critical processes; growth, apoptosis, metabolism, survival of the cells and specially differentiation. Several miRNAs such as miR-16 and miR-451 have been shown to be correlate...

This paper highlights the importance of product differentiation and endogenous r&d in determining the optimal r&d policy, in a model where investment in cost reducing r&d is committed before firms compete in a differentiated-goods third-country export market. R&D is always taxed in oligopolies for high degrees of product differentiation. For lower degrees of product differentiation the duopoly ...

To help guarantee profit and stability in today’s global market, companies must focus on the differentiation of their products. Successfully differentiated products will attract customers, generate revenue and benefit the brand image, whereas a banal product can lose money and leave a bad impression in the market. Many large companies have recently lost significant market share in part due to p...

1 Abstract Numerous manufacturing industries are seeking ways to reduce manufacturing costs and development times of product families through implementation of platform strategies. Deploying several variants from a single product platform can yield considerable savings in time, cost and maximize profits. It is, however, generally accepted that product platforms impose design and component reuse...

This article traces the strategic initiatives that Walmart undertook over the last decade to implement its ambitious vision of selling more sustainable products. This effort has been characterized by a gradual shift away from customer-facing initiatives aimed at labeling sustainable products toward supplier-facing initiatives targeted at improving environmental or social performance without rai...