This paper presents a strategy for matching features in multiple images, which emphasises reliable matching and the recovery of feature extraction errors. The process starts from initial ‘good’ matches, which are validated in multiple images using multi-image constraints. These initial matches are then filtered through a relaxation procedure and are subsequently used to locally predict addition...

The combined peak U.S. annual sales potential (excluding disease modification) for the PD indications alone is estimated to be in the range of $1.8bn to $2.7bn , (source Michael J Fox Foundation 2011). Datamonitor market research with PD specialists in the U.S., EU, China and India show that dipraglurant has an attractive product profile and can capture over $1 billion in annual revenues if ful...

The enantioselective addition of water to olefins in an aqueous environment is a common transformation in biological systems, but was beyond the ability of synthetic chemists. Here, we present the first examples of a non-enzymatic catalytic enantioselective hydration of enones, for which we used a catalyst that comprises a copper complex, based on an achiral ligand, non-covalently bound to (deo...

SOEs (sulfite-oxidizing enzymes) are physiologically vital and occur in all forms of life. During the catalytic cycle, the five-co-ordinate square pyramidal oxo-molybdenum active site passes through the Mo(V) state, and intimate details of the structure can be obtained from variable frequency pulsed EPR spectroscopy through the hyperfine and nuclear quadrupole interactions of nearby magnetic nu...

The use of alkaline phosphatase in an immunoenzymatic procedure for the localisation of antigens in paraffin sections or cell smears is described. The results of this method, when applied to the detection of immunoglobulins, lysozyme, or lactoferrin, were comparable in intensity and clarity to those obtained with the PAP immunoperoxidase procedure. Furthermore, double immunoenzymatic labelling ...

The lack of contextual integrity in region labelling schemes for segmented visual images has been a long standing problem in computer vision. In the past it has been common to adopt some form of relaxation scheme, such as relaxation labelling, to remove both labelling ambiguities and labellings which, usually, are obviously contextually incorrect. So far no general region labelling system has b...

We prove an analog of the classical Hartogs extension theorem for CR L2 functions defined on boundaries of certain (possibly unbounded) domains on coverings of strongly pseudoconvex manifolds. Our result is related to a question formulated in the paper of Gromov, Henkin and Shubin [GHS] on holomorphic L2 functions on coverings of pseudoconvex manifolds.

The sun protection factor (SPF) of sunscreens is determined by a testing protocol that specifies a sunscreen application rate of 2 mg/cm(2) on the skin. Most people, for cosmetic and economic reasons, only apply enough sunscreen to achieve an SPF of about a third or even a quarter of the level stated on the product. To increase public awareness of the problem, manufacturers could be required to...

Trading pharmaceutical products through the Internet poses several challenges related to legal responsibilities, good distribution practices, information content and patient use, financial implications, but also regarding product quality. One of the major concerns is the well-known phenomenon of counterfeited and/or substandard drugs commercialized through rogue Internet sites. Therefore, contr...