Introduction: Interleukin-2 (IL-2) as a T helper type 1 (Th1) cytokine has an important role Background and Objective: Interleukin-2 (IL-2) as a T helper type 1 (Th1) cytokine has an important role in activation, growth and differentiation of several immune cells. Moreover IL-2 is known as a pro-inflammatory and anti-tumoral cytokine. In addition deysregulation of IL-2 in some diseases such as ...

The buffer allocation problem is an NP-hard combinatorial optimization problem, and it is an important design problem in manufacturing systems. The research proposed in this paper concerns a product line consisting of n unreliable machines with n − 1 buffers and a preventive maintenance policy. The focus of the research is to obtain a better trade-off between the buffer level ...

We present a model and analysis of a production line that processes different part types on unreliable machines which operate according to a priority rule. The production line consists of machines separated by storage areas in which parts flow in a fixed sequence. A machine operates on the highest priority part whenever possible, and only operates on lower priority parts when unable to produce ...

Fourteen Epstein-Barr virus (EBV)-negative cell lines were raised from bone marrow (BM), peripheral blood (PB), or lymph node samples of patients with intermediate- or high-grade malignant lymphoma. The cell lines were propagated in liquid suspension culture. They contain clonogenic progenitors capable of forming lymphoma colonies in semi-solid culture medium. Cells of these lines were used to ...

Lentiviral vectors (LV) represent a key tool for gene and cell therapy applications. The production of these vectors in sufficient quantities for clinical applications remains a hurdle, prompting the field toward developing suspension processes that are conducive to large-scale production. This study describes a LV production strategy using a stable inducible producer cell line. The HEK293 cell...

Creutzfeldt-Jakob disease (CJD), a progressive dementia of humans, is caused by an infectious agent that is closely related to the scrapie agent of sheep. Although the molecular nature of these "unconventional" agents is still a matter of speculation and controversy, even less is known concerning the mechanism(s) of their effects on the central nervous system. To gain insight into the cellular ...

We reported at the Keynote Forum of Immunology Summit-2015 that recombinant human (rh) TNF-α or rhIL-6 stimulated production of matrix metalloproteinase-9 (MMP-9) in the T/C28a2 and C-28/I2 human immortalized chondrocyte cell lines. Furthermore, we reported that tocilizumab (TCZ), a fully humanized monoclonal antibody which neutralizes IL-6-mediated signaling, inhibited the rhIL-6-mediated incr...

Image-processing systems are applied at many stages of production lines, such as manufacturing/assembly and visual inspection. Because changes take place frequently in production lines, as in facility or component alterations, image-processing programs need to be developed and/ or modified promptly to accommodate those changes. Using one of the machine learning techniques—Genetic Programming—Fu...

The effect of the various design factors on the production rate in a parallel line is discussed by a Markov model and the difference of the effect between parallel lines and series lines is represented. A simple and effective scale is proposed to evaluate the availability of a parallel line and the production rate of a parallel line is approximately estimated by the scale and the relation betwe...