BACKGROUND The prognostic value of tumor-infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) remains controversial. Additionally, there is no standardized approach or cutoff value for evaluating TIL levels. The aim of this study was to establish a feasible method and criterion to assess TIL levels for future clinical practice and research use and to explore the rela...

BACKGROUND The aim of this study was to investigate the potential value of apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) in the prognosis of patients with hyperacute cerebral infarction (HCI) receiving intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA). MATERIAL AND METHODS From June 2012 to June 2015, 58 cases of HCI (<6 h) undergo...

the aim of this study was investigating the characteristic and outcome of self-immolation cases admitted to the burn centre of birjand, iran over an eight year period. this study is a retrospective review of case notes for patients with self-immolation and admitted to our referral burn centre in the last 8 years (january 2003-january 2011). a performa was designed to collect the data such as: d...

background: acute methanol poisoning is one of the most important chemical poisoning due to drinking of illegal and handmade alcoholic beverages in iran. the aim of this study was to evaluate clinical and biochemical parameters as prognostic factor in acute methanol poisoning. methods: a retrospective study was performed on acute methanol poisoning cases admitted to the loghman hakim hospital p...

today, the treatment of patellar luxations using current techniques has become a very common procedureas part of the surgical treatment. nevertheless, there are some doubts about such procedures in restraining the patella in lower grade cases. the purpose of the present retrospective clinical study was to determine theefficacy of the soft tissue and bone reconstructive procedures used for vario...

background: acute myeloid leukemia (aml) is a malignant disorder involving blood cells, characterized by obstructed or distorted differentiation of hematopoietic stem cells. in cytogenetically normal aml (cn aml), molecular abnormalities in npm, flt3, cebpa, and baalc genes are observed. initially, high baalc (brain and acute leukemia cytoplasmic gene) expression was introduced in a study on am...

BACKGROUND Alcohol dehydrogenase (ADH) isoenzymes have been reported as a potential diagnostic marker for pancreatic cancer, but their prognostic value in pancreatic cancer remains unclear. The aim of this investigation was to identify the prognostic value of ADH genes in human patients with pancreatic adenocarcinoma (PAAD). MATERIALS AND METHODS An RNA sequencing dataset and corresponding su...

BACKGROUND Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy. METHODS Frozen primary tumors were collected from 126 lymph node-negative and adjuvant therapy-naive TNBC patients. These samples were used for global pro...

The anatomic disease extent or tumour stage of a cancer at diagnosis as a determinant of prognosis is discussed. The importance of cancer stage in individual patient prognosis and determination of treatment is reviewed as well as its value in research and cancer control activities. The conflict between the need for stability of cancer stage definitions over time and the need to evolve with adva...

Improving value in health care is of paramount importance, and doing so will require focus on both the costs and benefits of care. Palliative care addresses symptoms of disease regardless of prognosis, helps patients clarify their goals of care, and is key in improving value in the health care system.