Expression of the bcl-2 gene has been shown to effectively confer resistance to programmed cell death under a variety of circumstances. However, despite a wealth of literature describing this phenomenon, very little is known about the mechanism of resistance. In the experiments described here, we show that bcl-2 gene expression can result in an inhibition of cell division cycle progression. The...

Programmed cell death involves a complex and interrelated cascade of cysteine proteases termed caspases that are synthesized as inactive zymogens, which are proteolytically processed to active enzymes. Caspase-8 is an initiator caspase that becomes activated when Fas death receptor-Fas ligand (FasL) coupling on the cell surface leads to coalescence of a "death complex" perpetuating the programm...

abstract background: we aimed to evaluate an approach to induced abortions during early pregnancies that controls the suction pressure and restricts the duration of the procedure. methods: three hundred patients programmed for induced early pregnancy abortions, hospitalized in the shandong provincial maternity & child care hospital from october 2013 to october 2015, were enrolled. patients were...

The discovery of probabilistic promoter switches in genes that code for class I major histocompatibility complex receptors in mouse and human provides a useful paradigm to explain programmed cell fate decisions. These switches have preset probabilities of transcribing in either the sense or antisense direction, and the characteristics of individual switches are programmed by the relative affini...

Medical management, is a team work and the nature of clinical toxicology is multidisciplinary. Internal organs problems following intoxications are included in field of internal medicine; similar problems in poisoned children brings pediatric medicine into the arena. The emergency nature of many acute intoxications, the legal problems of poisoned patients, respiratory assist in unconscious case...

sorption, danazol was replaced by azathioprine and a third course of vincristine was given. Six days later, the platelet count began to rise. Pharmacologic therapy was tapered down until withdrawal and the patient is in complete remission so far. Snyder et al. reported in 1992 a durable response in 36% of refractory ITP patients treated with Prosorba columns. The clinical response was associate...

OPTCON is an algorithm for the optimal control of nonlinear stochastic systems which particularly applicable to economic models. It delivers approximate numerical solutions optimum (dynamic optimization) problems with a quadratic objective function models additive and multiplicative (parameter) uncertainties. The was first programmed in C# then MATLAB. allows deterministic control, latter open ...

|The method of programmed constraints has recently been proposed as an executable speci cation language for robot programming. The mathematical structures behind such problems are viability problems for control systems described by ordinary di erential equations (ODEs) subject to user-de ned inequality constraints. This paper describes a method for the numerical solution of such viability probl...

| The method of programmed constraints has recently been proposed as an executable speciication language for robot programming. The mathematical structures behind such problems are viability problems for control systems described by ordinary diierential equations (ODEs) subject to user-deened inequality constraints. This paper describes a method for the numerical solution of such problems , imp...