Gaucher's cells have been extensively investigated morphologically and biochemically, and it is now thought that they represent histiocytic cells in which large amounts of glucocerebroside have accumulated because of a deficiency of ,B-glucosidase (Brady, 1972). The histiocytic nature of Gaucher's cells has been inferred from their phagocytic ability (Lee et al., 1967), high lysosomal enzyme co...

littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. this report describes a case of littoral cell angioma with no malignant histological features. the lesion is composed of anastomosing vascular channels resembling splenic sinus; they are lined by endothelial cells which show mitotic activity very rare. immunohistochemically, the...

Kikuchi's disease (necrotising lymphadenitis) is characterised by cervical lymphadenopathy in young patients and may be mistaken for malignant disease both clinically and histologically. Microscopically, there is a varying degree of effacement of the lymph node architecture and necrosis with an infiltrate of "histiocytic" cells and absence of polymorphs. The disease is of unknown aetiology. It ...

Weber-Christian disease (WCD) is an inflammatory disease of subcutaneous fat first described in 1892. Panush et al. I analysed the clinical and laboratory features of WCD, including chronic relapsing fever with subcutaneous non-sup­ purative nodules predominantly on lower extremities, arthralgia or ar­ thritis and myalgia. The laboratory features were elevated erythrocyte sedimentation rate, an...

Accepted 16 February 2018 DesCripTion A 2-month-old full-term male infant presented with worsening tachypnoea and a rapidly enlarging, smooth-topped, infiltrative, bronze-yellow nodule with overlying telangiectasias on the mid-sternum (figure 1A). CT imaging demonstrated multiple pulmonary nodules, and enhancing extradural masses compressing the L4–L5 vertebral neural foramina. Immunohistochemi...

Histiocytic sarcoma (HS) is a very rare lympho hematopoietic malignant neoplasm. Up to date, only a small number of gastric histiocytic sarcoma has been reported. In the present study, we reported a case of a primary huge histiocytic sarcoma of stomach in a youth man of 20 years old. Imaging examinations showed a large mass in the lesser curvature and antrum of the stomach. Then a distal subtot...

Examination of gene functions in specific tumor types improves insight in tumorigenesis and helps design better treatments. Due to the rarity of histiocytic/dendritic cell sarcoma in humans, it is difficult to accrue such knowledge. Therefore, comparative research of these cancers in predisposed dog breeds, such as the Flatcoated retriever, can be of value. Histiocytic sarcoma in the dog can be...