نتایج جستجو برای: promethazine
تعداد نتایج: 522 فیلتر نتایج به سال:
Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we combined a literature discovery approach with analysis of a large electronic medical record database method to predict and evaluate novel DDIs. We predicted an initial set of 13197 potential DDIs based on substrates and inhibitors of cytochrome P450 (CYP) metabolism enzymes identified from published in vi...
Spaceflight is known to induce vestibular and cardiovascular deconditioning. Consequently, astronauts suffer from orthostatic intolerance and spatial disorientation upon return to a gravitational environment. The aim of the current ESA SPIN-D study was to identify the most appropriate pharmacological countermeasure against the aforementioned symptoms. This double blind placebo controlled study ...
First chemoenzymatic stereodivergent synthesis of both enantiomers of promethazine and ethopropazine
Enantioenriched promethazine and ethopropazine were synthesized through a simple and straightforward four-step chemoenzymatic route. The central chiral building block, 1-(10H-phenothiazin-10-yl)propan-2-ol, was obtained via a lipase-mediated kinetic resolution protocol, which furnished both enantiomeric forms, with superb enantioselectivity (up to E = 844), from the racemate. Novozym 435 and Li...
IN the original publication on chlorpromazine, Courvoisier and her associates (1953) reported that this phenothiazine potentiated the intensity and duration of action of analgesic drugs in animals. They did not, however, show that chlorpromazine itself possessed any analgesic action. Schneider (1954) also found that it increased the duration of morphine analgesia in mice. Kopera and Armitage (1...
First chemoenzymatic stereodivergent synthesis of both enantiomers of promethazine and ethopropazine
how to cite this article: derakhshanfar h, modanlookordi m, amini a, shahrami a. a comparative study of the sedative effect of oral midazolam and oral promethazine medication in lumbar puncture. iran j child neurol. 2013 spring;7(2):11-16. objective lumbar puncture (lp) essentially is a painful and stressful procedure that indicated for diagnosis and therapeutic purposes. one way to reduce th...
Acute pain management in opioid dependent patients remains a challenging and complex problem and it is becoming more common (1). In the acute pain setting, in addition to their daily opioid maintenance these patients need a multimodal approach (1). Imani et al. in their study have shown that instead of simply increasing the dosage of morphine, using morphine in addition to chlorpromazine, prome...
The objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. A 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [X1] and concentra...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید