Activation of transcription by the SV40 enhancer decreases in an apparently biphasic manner when DNA sequences are interposed between the SV40 enhancer and either the homologous SV40 early or the heterologous conalbumin promoter elements. With increasing lengths of short DNA fragments (up to about 150 bp) activation of transcription decreases to less than 10% of the maximum. This short range ef...

Phenobarbital (PB) alters expression of numerous hepatic genes, including genes involved in xenobiotic metabolism. Phenobarbital-dependent induction of cytochrome P-450 2B1 (CYP2B1) is subject to regulation by cytokines [e.g., by epidermal growth factor (EGF)], hormones [e.g., by growth hormone (GH)], or the cellular redox status. To investigate mechanisms involved in regulation of CYP2B1 trans...

Rodent-borne orthohantaviruses are asymptomatic in their natural reservoir, but they can cause severe diseases humans. Although an exacerbated immune response relates to hantaviral pathologies, have antagonize the antiviral interferon (IFN) successfully propagate infected cells. We studied interactions of structural and nonstructural (NSs) proteins pathogenic Puumala (PUUV), low-pathogenic Tula...