Oxidative stress and the generation of reactive oxygen species (ROS) can lead to mitochondrial dysfunction, DNA damage, protein misfolding, programmed cell death with apoptosis and autophagy, and the promotion of aging -dependent processes. Mitochondria control the processing of redox energy that yields adenosine triphosphate (ATP) through the oxidation of glucose, pyruvate, and nicotinamide ad...

The remnant liver's ability to regenerate may affect post-hepatectomy immediate mortality. The promotion of autophagy post-hepatectomy could enhance liver regeneration and reduce mortality. This study aimed to identify predictive factors of immediate mortality after surgical resection for hepatocellular carcinoma (HCC). A total of 535 consecutive HCC patients who had undergone their first surgi...

Objective: Autophagy is necessary for the progression of psoriasis. This study aimed to recognize possible autophagy-related genes in psoriasis via bioinformatics present a better standard clinical treatment and management Methods: The GEO dataset was utilized derive mRNA expression profile database GSE78097. R software find autophagy-associated that may be expressed Then, Protein-protein inter...

Cellular reprogramming is accompanied by a metabolic shift from oxidative phosphorylation (OXPHOS) toward glycolysis. Previous results from our laboratory showed that hypoxia alone is able to reprogram primordial germ cells (PGCs) into pluripotency and that this action is mediated by hypoxia-inducible factor 1 (HIF1). As HIF1 exerts a myriad of actions by upregulating several hundred genes, to ...

Magnetic nanoparticles (NPs) of superparamagnetic iron oxide (SPIO) have been explored for different kinds of applications in biomedicine, mechanics, and information. Here, we explored the synthetic SPIO NPs as an adjuvant on antigen cross-presentation ability by enhancing the intracellular delivery of antigens into antigen presenting cells (APCs). Particles with different chemical modification...

Ageing involves a time-dependent decline in a variety of intracellular mechanisms and is associated with cellular senescence. This can be exacerbated by prion diseases which can occur in a sporadic manner, predominantly during the later stages of life. Prions are infectious, self-templating proteins responsible for several neurodegenerative diseases in mammals and several prion-forming proteins...

Abstract Background Long non-coding RNAs (lncRNAs), a class of (ncRNAs) associated with diverse biological processes cells. Over the past decades, cumulating research evidences revealed that abnormal expressions lncRNAs are colorectal cancer (CRC) initiation, progression, metastasis, and resistance to therapies. Moreover, their usefulness as candidate biomarkers for CRC diagnosis prognosis well...

Abstract Edwardsiella piscicida is an intracellular pathogenic bacterium accounting for significant losses in farmed fish. Currently, cellular and molecular mechanisms underlying E. piscicida–host cross-talk remain obscure. In this study, we revealed that could increase microtubule-associated protein L chain 3 (LC3) puncta grass carp (Ctenopharyngodon idella) monocytes/macrophages a cell line, ...

Abstract Autophagy plays an active anti-viral role in plants. Increasing evidence suggests that viruses can inhibit or manipulate autophagy, thereby winning the arms race between plants and viruses. Here, we demonstrate overexpression of m 6 A writer from Solanum lycopersicum , SlHAKAI, could negatively regulate pepino mosaic virus (PepMV) infection, viral RNA protein accumulations by affecting...

how the seeds of delphinium staphisagria promote hair growth in humans is yet to be discovered. this lack of information leads us to the investigation of hair promoting effects of seeds of delphinium staphisagria in vitro. extract prepared from the seed of delphinium staphisagria (esds) - traditionally used for hair loss treatment - was selected and tested for the cytotoxic and angiogenic poten...