Details of the discovery of ubiquinone (coenzyme Q) are described in the context of research on mitochondria in the early 1950s. The importance of the research environment created by David E. Green to the recognition of the compound and its role in mitochondria is emphasized as well as the dedicated work of Karl Folkers to find the medical and nutritional significance. The development of divers...

Introduction: Reactive oxygen and nitrogen species (RONS) are produced as a response to exercise play part in guiding the adaptive physical training. Exercise heat has been shown further increase accumulation of RONS systemic circulation; however, high anti-oxidative or acclimatization mechanisms could attenuate this response. In previous study, we found reduced concentrations trained athletes ...

The study was conducted on 50 chronic renal failure patients who were undergoing hemodialysis for atleast a period of 6 months. Samples were drawn before and after hemodialysis comprising of two groups A and B. Group C 50 age and gender matched healthy individuals were taken as controls. Serum Malondialdehyde (MDA) when estimated showed significant increase in postdialysis patients when compare...

the present study was carried out to evaluate the antioxidant and free radical scavenging activity of methanolic extract of ervatamia coronaria leaves (apocynaceae) in various systems. dpph radical, superoxide anion radical, nitric oxide radical and hydroxyl radical scavenging assays were carried out to evaluate the antioxidant potential of the extract. the antioxidant activity of methanolic ex...

Since metals are cable of catalysing the free radical reactions, different metal (Mg, Mn, Zn) compounds were studied to determine their hydroxyl radical generating and/or scavenging abilities depending on ligand in a H2O2/OH -luminol system with or without microperoxidase. Magnesium oxide, magnesium gluconate and manganese gluconate increase the free radical reactions in the H2O2/OH -luminol sy...

Free radicals and antioxidants are widely discussed in the clinical and nutritional literature. Antioxidants are needed to prevent the formation and oppose the actions of reactive oxygen and nitrogen species, which are generated in vivo and cause damage to DNA, lipids, proteins, and other biomolecules. Endogenous antioxidant defenses (superoxide dismutases, H2O2-removing enzymes, metal binding ...

The aim of this study was to assess the effect of a combined 14-day treatment with rosuvastatin (10 mg/kg) and fluoxetine (10 mg/kg) on selected biochemical parameters of oxidative stress in the blood of rats. The activity of glutathione peroxidase (GPX), glutathione reductase (GR) and the total antioxidant status (TAS) were determined. A combined 14-day treatment with rosuvastatin and fluoxeti...

The bioequilibrium of antioxidant and prooxidant has a crucial role in cellular function with free radical defense (Valko et al., 2006). Oxidative stress is defined by the excess of free radicals and antioxidant depletion. It was implicated on biomolecules such as protein, lipid, and nucleic acid (Sies, 1997; Finkel & Holbrook, 2000). Cellular oxidative stress eventually caused tissue injury an...

The present work describes the isolation of α - and β -carotene from crude palm oil and their antioxidant potential in an in vitro model. Pure product was isolated by the method adopted. Antioxidant activities of the isolated α - and β -carotene were analyzed in five different concentrations of 0.001, 0.005, 0.01, 0.05, and 0.1% (w/v). From the several assays conducted, an observation was made ...