Simulating future events is dependent on a similar neural circuitry to that which supports retrieving contextual information about past events. The current study examined two novel predictions from recently reported episodic future simulation studies. Prospective memory is broadly defined as the usage of episodic memory processes to encode and retrieve intentions at some appropriate moment in t...

Individuals with schizophrenia experience a range of cognitive deficits and associated dysfunctions in the neural systems that support cognitive processes. This chapter reviews the literature on disturbances in working memory, executive control, and episodic memory in schizophrenia. Advances in basic cognitive neuroscience are described to help explain the cognitive neuroscience of schizophreni...

Growing interest is present in literature on the study of prospective memory functioning in Parkinson's disease (PD). Current data indicate that prospective memory may be impaired in PD and a relationship with general executive dysfunctioning has been suggested. However, although the dopamine dependency of cognitive dysfunction in PD has been widely investigated, poor is known on the dopaminerg...

OBJECTIVE Deficits in working memory and in prefrontal cortical physiology are important outcome measures in schizophrenia, and both have been associated with dopamine dysregulation and with a functional polymorphism (Val(108/158)Met) in the catechol O-methyltransferase (COMT) gene that affects dopamine inactivation in the prefrontal cortex. The purpose of the present study was to evaluate in p...

OBJECTIVES The goals of this study were to measure the neurocognitive performance of recent users of recreational Ecstasy and investigate whether it was associated with the stress hormone cortisol. METHODS The 101 participants included 27 recent light users of Ecstasy (one to four times in the last 3 months), 23 recent heavier Ecstasy users (five or more times) and 51 non-users. Rivermead par...

OBJECTIVE Schizophrenia and bipolar disorder are characterized by the presence of neurocognitive impairments on the psychosis continuum. The present study aimed to explore the shared and distinct endophenotypes between these disorders. METHODS The study included 34 probands with remitted schizophrenia and 34 probands with euthymic bipolar disorder who had a history of psychotic symptoms that ...

introduction : shared neuropathology hypothesis in schizophrenia and temporal lobe epilepsy has been introduced long term ago. similar neuropathology leads to the analogous clinical features like neuropsychological features as an example. the aim of this study was to examine this hypothesis by the means of comparing neuropsychological functions in these two patient groups. method : present stud...

Although disturbed sleep is a prominent feature of schizophrenia, its relation to the pathophysiology, signs, and symptoms of schizophrenia remains poorly understood. Sleep disturbances are well known to impair cognition in healthy individuals. Yet, in spite of its ubiquity in schizophrenia, abnormal sleep has generally been overlooked as a potential contributor to cognitive deficits. Ameliorat...

BACKGROUND Social dysfunction is a hallmark characteristic of schizophrenia. Part of it may stem from an inability to efficiently encode social information into memory and retrieve it later. This study focused on whether patients with schizophrenia show a memory boost for socially relevant information and engage the same neural network as controls when processing social stimuli that were previo...