OBJECTIVE The effect of insulin-like growth factor-1 (IGF-1) on energy expenditure and protein and glucose metabolism in a group of patients with thermal injury was determined. SUMMARY BACKGROUND DATA Accelerated protein catabolism is a constant feature of the hypermetabolic response to thermal injury. Insulin-like growth factor-1 has been reported to minimize protein catabolism and normalize...

responsive to changes in the balance between protein anabolism and catabolism. The activity of this enzyme is low when conservation of protein is required for body growth. Thus, in the livers of immature rats, alanine transaminase is only one-fourth the level of that found in adult rat liver (11). Conversely, alanine transaminase activity in liver may be elevated by as much as sevenfold when gl...

Histamine intolerance occurs when there is an imbalance between histamine production and the capacity for degradation. Diamine oxidase (DAO) main enzyme catabolism of ingested degradation in gastrointestinal tract its deficiency has been linked to allergy-like symptoms. Psychostimulant drugs are commonly used treat Attention Deficit Hyperactivity Disorder (ADHD), but their interaction with DAO ...

Cystic fibrosis (CF) patients are reported to experience chronic protein catabolism. Since diabetes or impaired glucose tolerance (IGT) is common in CF, we hypothesized that their protein catabolic state is related to reduced insulin secretion or reduced insulin action. A total of 12 clinically stable adult CF patients with abnormal glucose tolerance and 12 age-, sex-, and lean body mass-matche...

The mTORC1 nutrient-sensing pathway integrates metabolic and endocrine signals into the brain to evoke physiological responses food deprivation, such as autophagy. Nevertheless, impact of neuronal activity on circuits organismal metabolism remains obscure. Here, we show that inhibition acutely perturbs serotonergic neurotransmission via proteostatic alterations evoked by autophagy inducer atg1....

The ability of the isolated perfused rat liver to catabolize plasma proteins has been investigated both with blood containing 131I-labelled isolated proteins (Gordon, 1957; Cohen & Gordon, 1958) and with blood containing whole plasma labelled with 14C (Green & Miller, 1960). Since the rate of catabolism obtained for albumin by the former method (1 1-1 4 mg. of albumin/hr.) is very much below th...

Background: Inflammation is a complex process mainly comprises of three phases namely acute, sub-acute and chronic. In acute inflammatory conditions fluid granulocytic cells accumulate at the site injury because changes in small blood vessels. This response often activates systemic such as leucocytosis, protein catabolism, fever synthesis C-reactive protein, an acute-phase Ayurvedic texts, seve...

Fish hatcheries must adapt larval feeding protocols to feeding behavior and metabolism patterns to obtain more efficient feed utilization. Fish larvae exhibit daily ingesting rhythms rather than ingesting food continuously throughout the day. The aim of this study was to determine the daily patterns of feed intake, protein digestibility, protein retention and catabolism in Senegalese sole post-...

A significant reduction of renal mass results in proteinuria, glomerulosclerosis, and tubulointerstitial injury, culminating in end-stage chronic renal failure (CRF). The accumulation of lipids in the kidney can cause renal disease. Uptake of oxidized lipoproteins via scavenger receptors, reabsorption of filtered protein-bound lipids via the megalin-cubilin complex, and increased glucose load p...

A substantial increase in the plasma concentration of most amino acids was observed in 59 preterm infants with chronic lung disease soon after the initiation of dexamethasone therapy. The size of increase appeared to be dose related. This phenomenon is likely to be the result of steroid induced protein catabolism. Interestingly, neither phenylalanine nor tyrosine concentrations were significant...