The growth and differentiation of normal cells are controlled by protein-tyrosine kinases, which serve as receptors for a wide variety external signals. Small protein modules called Src homology 2 (SH2) SH3 domains mediate protein-protein interactions in signaling pathways that triggered tyrosine kinases. SH2 domain, module around 100 amino acids, is present kinase targets within the cell. recr...

conclusions the comprehensive analysis of a protein with important roles has never been easy, and in case of e2 envelope glycoprotein of hgv, there is no much data on its molecular and immunological features, clinical significance and its pathogenic potential in hepatitis or any other gbv-c related diseases. so, results of the present study may explain some structural, physiological and immunol...

The phosphorylation of specific membrane proteins by endogenous protein kinase in synaptic membrane fractions from rat cerebrum has been studied using the technique of acrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The endogenous phosphorylation of two specific membrane proteins was found to be regulated by adenosine 3’ : 5’-monophosphate (cyclic AMP). The minimal mol...

Abstract Background Sterile alpha motif and HD domain 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that restricts the infection of variety RNA DNA viruses, including herpesviruses. The anti-viral function SAMHD1 associated with its dNTPase activity, which regulated by several post-translational modifications, phosphorylation, acetylation ubiquitination. Our recent studies also ...

objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...

Accumulating data suggest that the target cells for selection events leading to establishment of the mature T cell repertoire are the functionally immature double-positive (CD4+/CD8+) thymocytes, and that the CD4 and CD8 antigens expressed on these cells play important roles in these processes. In an attempt to define the biochemical pathways implicated in these events, we have studied the effe...

We review the role of signaling pathways in regulation key processes merozoite egress and red blood cell invasion by Plasmodium falciparum and, particular, importance second messengers, cAMP Ca 2+ , cyclic nucleotide dependent kinases. cAMP-dependent protein kinase (PKA) is comprised cAMP-binding regulatory, catalytic subunits. The less well conserved pockets should make analogs attractive drug...