UNLABELLED Conserved domains represent essential building blocks of most known proteins. Owing to their role as modular components carrying out specific functions they form a network based both on functional relations and direct physical interactions. We have previously shown that domain interaction networks provide substantially novel information with respect to networks built on full-length p...

SMART (Simple Modular Architecture Research Tool) is an online resource (http://smart.embl.de/) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 7 contains manually curated models for 1009 protein domains, 200 more than in the previous version. The current release introduces several novel features and a streamlined user int...

UNLABELLED : Identifying chemical probes or seeking scaffolds for a specific biological target is important for protein function studies. Therefore, we create the Annotated Scaffold Database (ASDB), a computer-readable and systematic target-annotated scaffold database, to serve such needs. The scaffolds in ASDB were derived from public databases including ChEMBL, DrugBank and TCMSP, with a scaf...

Reliable in silico design of synthetic gene networks necessitates novel approaches to model the process of protein synthesis under the influence of limited resources. We present such a novel protein synthesis model which originates from the Ribosome Flow Model and among other things describes the movement of RNA-polymerase and ribosomes on mRNA and DNA templates, respectively. By analyzing the ...

In this study, we mined the PDB and created a structural library of 178,465 interfaces that mediate protein–protein/domain–domain interactions. Interfaces involving same CATH fold(s) were clustered together. Our analysis reveals similarities between chain–chain domain–domain The also illustrates how single protein fold can interact with multiple folds using similar interfaces. is hence useful r...

Text mining approaches can accelerate the process of assembling knowledge from literature. In this abstract, we present our effort in assembling a resource for protein mutationdisease relations assembled from literature. Keywords—literature mining; protein mutation-disease

UNLABELLED Salt bridges can play important roles in protein structure and function and have stabilizing and destabilizing effects in protein folding. ESBRI is a software available as web tool which analyses the salt bridges in a protein structure, starting from the atomic coordinates. In the case of protein complexes, the salt bridges between protein chains can be evaluated, as well as those am...

World production of shelled almonds has reached 3.2 million tonnes (FAO 2020). Almond grown during the last decennium, also because consumer conviction that have significant health benefits. Almonds exceptional nutritional and organoleptic characteristics, proper assessment quality is utmost importance. a value relatively low in total sugars (4.35 g/100 g almonds) but rich lipids, proteins, min...

recombinant protein purification is a kind of sensitive and expensive method in genetics engineering. genetic manipulation leads to the expression of various proteins; it should be isolated with high purity finally. differed methods for protein purification are categorized, based on cast, quality, easy work and side effect of protein. in this article, we are investigating his his-tag protein pu...