abstract: warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties. na valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. interaction between warfarin and psychotropic drugs including valproate ar...

Li J, Al-Khalili O, Ramosevac S, Eaton DC, Denson DD. Proteinprotein interaction between cPLA2 and splice variants of -subunit of BK channels. Am J Physiol Cell Physiol 298: C251–C262, 2010. First published November 25, 2009; doi:10.1152/ajpcell.00221.2009.—Altering the splice variant composition of large-conductance Ca -activated potassium (BK) channels can alter their activity and apparent se...

The recent mapping of the human genome has opened the way to novel technologies for identifying new genes or clustering regulated genes and proteins in a tissueand cellspecific manner. Microarray and serial analysis of gene expression (SAGE) are quite powerful in this regard, and they generate on a day-to-day basis data banks of gene profile from cells or tissues of animals challenged with diff...

drug-food interactions can increase or decrease drug effects, resulting in therapeutic failure or toxicity. activities that reduce these interactions play an important role for clinical pharmacists. this study was planned and performed in order to determine the role of clinical pharmacist in the prevention of absorption drug-food interactions through educating the nurses in a teaching hospital ...

data collected in 2012 on 400 chickens were subjected to two-way analyses of variance to estimatebody weight, morphometric traits as well as the correlationbetween body weight and morphometric traitsin isa brown and ilorin ecotypechickens. the studied morphometric traits were comb length, beak length,head length, neck length, body length, wing length, shank length, thigh length, toe length, bre...

the interaction of biomolecules with carbon nanotubes (cnts) has generated a great deal ofinterest in the past few years. the interaction between b-form single-strand dna (ssdna) andsingle-walled carbon nanotubes (swcnts) is a subject of intense current interest; however thereare a relatively small number of papers in the literature dealing with interaction of dna andswcnts. in this work we inv...

meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. meningococcal disease has a rapid onset with high mortality. the understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

Since ancient times, a face with fair skin is considered as a sign of beauty and the demand for young, healthy, bright and fair skin has created a whitening cosmetics market. The color of human skin and hair established through a number of factors. Melanogenesis i.e. the biosynthesis of melanin is the major factor. It is a multistage process involving melanin synthesis in special organelles cal...