Spontaneous remission is a well known characteristic of idiopathic membranous nephropathy, but contemporary studies describing predictors of remission and long-term outcomes are lacking. We conducted a retrospective, multicenter cohort study of 328 patients with nephrotic syndrome resulting from idiopathic membranous nephropathy that initially received conservative therapy. Spontaneous remissio...

Exercise-induced proteinuria is a common consequence of physical activity and is caused predominantly by alterations in renal hemodynamics. Although it has been shown that exercise-induced oxidative stress can also contribute to the occurrence of postexercise proteinuria, the sources of reactive oxygen species that promote it are unknown. We investigated the enzymes nicotinamide adenine dinucle...

BACKGROUND Diabetic nephropathy with overt proteinuria often progresses relentlessly to end-stage renal disease (ESRD). MATERIAL AND METHODS To answer the question whether it is impaired glomerular filtration rate (GFR) or its precursor proteinuria which is more related with multiple domains of health-related quality of life (HRQOL), we measured GFR and proteinuria in 44 patients with type 2 ...

Glomerular diseases are the leading cause of ESKD worldwide. IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS), Alport syndrome (AS), and diabetic kidney disease (DKD) important glomerular characterized by proteinuria, a predictor progression ESKD. Endothelin A (ETA) receptor activation drives inflammation, fibrosis. Therefore, atrasentan, potent selective ETA antagonist, has po...

Dear Editor, Wilson’s disease (WD) is a rare autosomal recessive disorder of copper homeostasis with a prevalence of 30 affected individuals per million population. Treatment is based on oral chelating agents such as D-penicillamine. Despite its effectiveness, Dpenicillamine presents significant adverse effects. Among them is proteinuria and nephrotic syndrome. An 11 yearold boy was admitted wi...

Abstract Background and Aims Belatacept conversion is associated with an improvement in kidney allograft function. Yet, not all transplant recipients (KTRs) seem to benefit equally from this alteration of maintenance immunosuppression. Both type (alloimmune vs. non-alloimmune) severity (assessed by proteinuria) injury may impact the functional response a belatacept conversion. Method We studied...

Objective To assess for the presence of a sex interaction in the associations of estimated glomerular filtration rate and albuminuria with all-causemortality, cardiovascular mortality, and end stage renal disease. DesignRandom effects meta-analysis using pooled individual participant

INTRODUCTION The urinary protein/creatinine ratio has been used instead of 24-hour proteinuria in Nephrology practice for the follow-up of glomerular diseases, considering the advantages of collection and the low cost. However, there are still doubts as to its applicability both for an isolated evaluation and for the follow-up of patients with lupus nephritis. OBJECTIVE To evaluate 24-hour pr...

INTRODUCTION A range of malignant diseases (both solid organ tumors and hematogenous malignancies) may manifest as proteinuria/nephrotic syndrome. Multiple myeloma (MM) typically involves the kidneys and proteinuria, and chronic kidney disease (CKD) may also be the first manifestation of MM. OBJECTIVES The aim of the study was to evaluate the prevalence and clinical significance of abnormal s...