Inhibition of Proteus vulgaris B-lactamase by a new B-lactam antibiotic, PS-5 was studied kinetically. There were two stages of inhibition. In the early stage, PS-5 inhibited the Blactamase by formation of a MICHAELIS-complex, and showed a competitive inhibition pattern with Kj-value of 0.22 uM (substrate, cephaloridine). After the formation of a MICHAELIScomplex between PS-5 and the enzyme, PS...

Background & Aims: Emergence of biofilm producing Proteus strains created a serious problem in the treatment of catheter-associated urinary tract infections. The aim of this research was to study biofilm production and plasmid pattern of proteus strains associated with Urinary tract infection. Methods: A total of 88 strains of Proteus were isolated from samples collected in hospitals of Kerman/...

objective proteus syndrome is an extremely rare, sporadic and progressive disorder. we describe a four-month-old male baby with central nervous system manifestations in this article. clinical presentation a four-month-old boy was admitted into our hospital with three tonic - clonic generalized seizure attacks which started from the day before admission. each seizure attack lasted less than 10 m...

The characteristic necropsy and histological appearances are described of nine cases of Proteus meningoencephalitis in neonates. One case which was not due to Proteus has been included because of the close similarity of the gross appearances of the brain. Umbilical sepsis in half the cases indicated that this is a common portal of entry of these organisms. That epidemiological factors may be of...

Proteus syndrome is a complex hamartomatous disorder characterized by multiple, diverse, somatic manifestations. We present a case in which severe, evolving CNS abnormalities were also exhibited. Imaging findings at presentation included hemimegalencephaly, subependymal calcified nodules, and periventricular cysts. Subsequently, dural sinus thrombosis developed. Eight previously reported patien...

The Proteus syntactic analyzer was developed starting in the fall of 1984 as a common base for all the applications of the Proteus Project . Many aspects of it s design reflect its heritage in the Linguistic String Parser, previously developed an d still in use at New York University . The current system, including the Restriction Language compiler, the lexical analyzer, and the parser proper, ...

Bioinformatics is as a bridge between life science and computer science: computer algorithms are needed to face complexity of biological processes. Bioinformatics applications manage complex biological data accessing distributed heterogeneous databases, and require large computing power. After introducing bioinformatics requirements, we present the architecture of PROTEUS, a Grid-based Problem ...

Cowden syndrome (CS) is a genetic disorder characterized by multiple benign tissue growths (i.e., hamartomas) and an increased risk of developing specific cancers, such as breast, thyroid, kidney, endometrial, or colorectal cancer (Genetics Home Reference, 2012). This genetic syndrome was named after a person diagnosed with the disorder (Lloyd & Dennis, 1963). CS is part of a larger syndrome ca...