Proton pump inhibitors (PPIs) are widely prescribed to treat a number of gastrointestinal (GI) disorders due to excessive acid production. While effective and safe, adverse renal effects have been increasingly described in epidemiological literature. The most well-documented adverse renal outcome is acute interstitial nephritis; however, association with overall acute kidney injury has also bee...

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While proton-pump inhibitors (PPIs) have beneficial therapeutic and prophylactic indications for many patients, increasing evidence suggests that these medications are not without risk; inpatient use of PPIs has been shown to increase the risk of hospital-acquired pneumonia by up to 30% [2]. Community-acquired pneumonia is also more common in patients who have started PPI therapy within the pas...

PURPOSE OF REVIEW This review summarizes adverse effects of potential proton pump inhibitors (PPIs), including nutritional deficiencies (B12 and magnesium), rebound acid hypersecretion, acute interstitial nephritis, gastric carcinoid tumor, cardiovascular risk with clopidogrel and PPI coprescription, bone fractures, enteric infections and pneumonia. An epidemiologic framework is applied to asse...

Proton pump inhibitors (PPIs) are among the most commonly prescribed drugs in clinical practice. Since the introduction of these potent acid-suppressing agents in the late 80s, they were listed in the Guinness Book of World Records as the most prescribed in human history. Yet, to be effective in inhibiting the proton pump enzyme (H+/K+ ATPase) in the parietal cells, these drugs should be taken ...

RATIONALE Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. OBJECTIVE To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in...

Proton pump inhibitors are commonly used in clinical practice for the treatment of peptic ulcer and gastroesophageal reflux and are well tolerated by the patients. Their use is rarely associated with hypersensitivity and anaphylactic reactions. According to the reports in the Uppsala Monitoring Center database the frequency of hypersensitivity reactions out of all reported adverse reactions for...

poor prognosis in community subjects. Am J Med 2009;122:679–686. 7. Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med 2009;122: 857–865. 8. Heidelbaugh J, Kim A, Chang R et al. Overutilization of proton-pump inhibitors: What the clinician needs to know. Therap Adv Gastroenterol 2012;5:219–232. 9. Ozdil K, Kahraman R, Sahin A e...

We describe the clinical scenario of a young male with history of non ulcer dyspepsia who had endoscopic evidence of gastric polyposis in antral area. The polyps disappeared four months after proton pump inhibitors were stopped. Proton pump inhibitors have been linked to gastric fundal polyposis and not antral gland polyposis. This is the first report originating from an Asian country describin...