Background Malaria is one of tropical and semi-tropical and vector-borne parasitic diseases produced by the protozoan parasites of the genus and species Plasmodium. The aim of this study was to assess the epidemiology and the factors associated with the malaria in children in Sistan and Baluchistan province in 2013-2016. Materials and Methods This cross-sectional study was conducted between Mar...

Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs. There are 1·3 million new cases each year causing considerable socio-economic hardship, best measured in 2·4 million disability adjusted life years, with greatest impact on the poorest communities, which means that des...

The aquatic communities found within the water filled leaves of the pitcher plant, Sarracenia purpurea, have a simple trophic structure providing an ideal system to study microscale interactions between protozoan predators and their bacterial prey. In this study, replicate communities were maintained with and without the presence of the bactivorous protozoan, Colpoda steinii, to determine the e...

Introduction The term “parasitic infestation” is used to refer to those infections caused by protozoa, helminthes, and arthropods. They are a major cause of morbidity and mortality in infants and children. However, parasitic infestations have received relatively little attention compared with infections due to viral, bacterial, and fungal agents. Parasitic infestations are a worldwide problem i...

The specificity and sensitivity of two commercial systems for the detection of anti-native deoxyribonucleic acid (DNA) antibodies in the diagnosis of active systemic lupus erythematosus were evaluated. Sera containing antinuclear antibodies from 64 patients were tested by an indirect immunofluorescent antibody technique employing the protozoan Crithidia luciliae as substrate and immunoradioassa...

Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b. rhodesiense HAT is a zoonosis. We review current knowledge on the burden of HAT in sub-Saharan Africa, with an emphasis on the disability-adjusted life year (DALY), data sources, and...

Chagas’ disease (American trypanosomiasis) is an infection of man and other mammals caused by the flagellated protozoan TryPanosoma cruzi. The human disease features prominently among the parasitic diseases of man in nearly all Latin American countries. An unusual feature of Chagas’ diseaseas compared with other diseases caused by pathogenic protozoa-is that the parasite develops inside cells o...

The search for new drugs that could treat tropical protozoan diseases, such as malaria or neglected tropical diseases (NTDs), motivates many medicinal chemists. New classes of antiprotozoal drugs that act through a novel mechanism of action must be developed. This review presents our efforts toward finding new candidate treatments for malaria, American trypanosomiasis, human African trypanosomi...

The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (...