The Psoralea corylifolia L. seed (PCS) is a widely used herbal medicine, but its possible effect against diabetic nephropathy has not been studied. To investigate the anti-nephropathic effect of PCS extracts, we performed experiments using a diabetic mouse model and high glucose-treated mesangial cells. Streptozotocin (STZ)-induced diabetic mice were orally administered PCS extract for 8 weeks ...

BACKGROUND Mild traumatic brain injury (mTBI) is being claimed as the 'signature' injury of the Iraq war, and is believed to be the cause of long-term symptomatic ill health (post-concussional syndrome; PCS) in an unknown proportion of military personnel. METHOD We analysed cross-sectional data from a large, randomly selected cohort of UK military personnel deployed to Iraq (n=5869). Two mark...

BACKGROUND Purkinje cells (PCs) are important in cardiac arrhythmogenesis. Whether small-conductance calcium-activated potassium (SK) channels are present in PCs remains unclear. We tested the hypotheses that subtype 2 SK (SK2) channel proteins and apamin-sensitive SK currents are abundantly present in PCs. METHODS AND RESULTS We studied 25 normal rabbit ventricles, including 13 patch-clamp s...

Dermis-derived mesenchymal stem/progenitor cells (DMS/PCs) were a multipotential stem cell population, which has potential applications in the tissue damage repair and skin transplant. Although a large number of studies deal with the human DMS/PCs self-renewal and regulation, however, the study of livestock-derived DMS/PCs has rarely been reported. Here, sheep DMS/PCs were isolated from one-mon...

The accumulation of oxidative damage and mitochondrial dysfunction is an important factor that contributes to aging. The Psoralea corylifolia seeds (PCS), commonly known as "Boh-Gol-Zhee" in Korea, have been used traditionally as a medicinal remedy. We investigated whether an extract of PCS has protective effects on oxidative stress and mitochondrial function in hepatocytes. The PCS extract sho...

The complex and highly specific nature of ICD-10-PCS has changed the query process for inpatient procedures. Each code is constructed using individual characters that identify all aspects of the procedure. Assigning the correct ICD-10-PCS code requires precise and complete documentation. Incomplete and non-specific documentation may result in the inability to assign a code. Unlike ICD-9-CM proc...

We present a systematic study of signal propagation conditions (PCs) starting from a general waveform model. We develop a number of specific waveform models based on how closely they match actual signal behavior, and show that they form a well-defined hierarchy. For each model, we derive PCs based on fundamental cause-and-effect behavior. We then construct a lattice of all known PCs that reveal...

This paper presents a framework illustrates the various trends that point toward the increasing importance of mobile device research in Human Computer Interaction (HCI). These trends indicate a future in which the gap between the user and the mobile is even closer than today and computer use is more intermittent and in a greater variety of contexts than our current user models accommodate. The ...

This paper proposes a system called Neary that detects conversational fields based on similarity of auditory situation among users. The similarity of auditory situation between each pair of the users is measured by the similarity of frequency property of sound captured by headworn microphones of the individual users. Neary is implemented with a simple algorithm and runs on portable PCs. Experim...