BACKGROUND Rare cases of birth defects after the use of methimazole (MMI) or carbimazole to treat hyperthyroidism in early pregnancy have been reported since 1972, whereas propylthiouracil (PTU) has not been considered teratogenic. Recently, two studies reported birth defects after the use of MMI in early pregnancy to affect 2-4% of exposed children, and one study also found birth defects after...

INTRODUCTION Poorly treated or untreated maternal overt hyperthyroidism may affect pregnancy outcome. Fetal and neonatal hypo- or hyper-thyroidism and neonatal central hypothyroidism may complicate health issues during intrauterine and neonatal periods. AIM To review articles related to appropriate management of hyperthyroidism during pregnancy and lactation. METHODS A literature review was...

Paroxysmal tonic upgaze (PTU) is a childhood oculomotor syndrome of unclear etiology characterized by episodic tonic upward eye deviation with neck flexion. Neuroimaging findings are often normal and the electroencephalography during episodes is typically normal. We describe a 2-year-old boy who presented with macrocephaly, hypotonia, developmental delay and episodes of eye fluttering, head nod...

Aims: The aim of this study was two-fold: i) to describe factors associated with antithyroid drug (ATD) treatmentduring gestation among women hyperthyroidism in pregnancy, ii) investigate the impact ATDtreatment during on pregnancy outcomes.Methods: Women and ATD treatments were identified through linkage ofthree national registries (2008-2018): Medical Birth Registry Norway, Norwegian Prescrip...

This research was conducted to determine the effect of Coenzyme Q10 (CoQ10) on blood glucose, total protein, triglyceride, and cholesterol levels in rats for that experimental hypothyroidism induced. A 32 healthy adult male Wistar Albino were used as a material research. After adaptation period animals ten days, main three weeks. The housed four each cage during divided into groups control (K),...

Background. Fetal tachycardia may result from the transplacental passage of thyroid stimulating immunoglobulins in a patient with hypothyroidism secondary to ablation of Graves' disease. Case. A 32-year-old woman, gravida 4, para 2, and abortus 1, with hypothyroidism and a history of Graves' disease, presented at 23 6/7 weeks of gestation with a persistent fetal tachycardia. The treatment of th...

Oxidative stress is known to be one of the major factors to induce germ cell apoptosis. In our earlier research, it was reported that neonatal persistent and transient hypothyroidism cause prevalence of oxidative stress marked by elevated lipid peroxide levels, protein carbonyl contents with decreased antioxidant enzyme levels. Alteration in germ cell population was also marked in persistent an...

This study was performed on 17 hyperthyroid patients and 15 healthy controls. The patients were under propylthiouracil (PTU) therapy at a dosage of 3 x 100 mg/day for one month. Blood samples, taken at the beginning and on the 30th day of therapy, were analyzed for hormonal parameters (T3, T4, TSH), lipid peroxidation endproduct [thiobarbituric acid reactive substances (TBARS)] and antioxidant ...