نتایج جستجو برای: pulmonary alveolar proteinosis
تعداد نتایج: 267954 فیلتر نتایج به سال:
We report a case of 58 year old female diagnosed with Pulmonary Alveolar Proteinosis (PAP) with recurrence of PAP after 5 repeated whole lung lavage, responding to subcutaneous injections of Granulocyte Macrophage Colony Stimulating Factor therapy (GM-CSF). Thus indicating that GM-CSF therapy is a promising alternative in those requiring repeated whole lung lavage
Pulmonary alveolar proteinosis (PAP) is a syndrome characterised by accumulation of proteinaceous, periodic acidSchiff positive material within airspaces due to disruption of surfactant homeostasis [1]. In 95% of cases, PAP is associated with increased serum levels of auto-antibodies neutralising granulocyte-macrophage colony-stimulating factor and, therefore, this form is referred to as ‘‘auto...
Two cases of pulmonary alveolar proteinosis were treated with bronchoalveolar lavage (BAL) via a fibreoptic bronchoscope. Additional clinical improvement was seen when trypsin was added to the lavage fluid. Analysis of effluents in the BAL fluid showed marked reduction of protein constituents with clinical improvement after treatment with trypsin in the lavage. BAL with trypsin was well tolerated.
Pulmonary Alveolar Proteinosis (PAP) is a rare syndrome characterized by pulmonary surfactant accumulation within the alveolar spaces. It occurs with a reported prevalence of 0.1 per 100,000 individuals and in distinct clinical forms: autoimmune (previously referred to as the idiopathic form, represents the vast majority of PAP cases, and is associated with Granulocyte-Macrophage Colony Stimula...
Previously, we reported the specific occurrence of neutralizing autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) in the bronchoalveolar lavage fluid from 11 Japanese patients with idiopathic pulmonary alveolar proteinosis (I-PAP). The autoantibody was also detected in sera from all 5 I-PAP patients examined. To determine that the existence of the autoantibody is ...
In 1958 Rosen, Castleman, and Liebow described 27 patients with a newly-recognized pulmonary disease which they called pulmonary alveolar proteinosis (PAP). Since then approximately 100 cases have been reported. These are reviewed by Davidson and Macleod (1969). Only once has this condition been reported in early infancy. Wilkinson, Blanc, and Hagstrom (1968) described two babies who presented ...
Alveolar proteinosis is a rare disease characterized by the accumulation of a proteinoseous material inside the alveolus. Various forms of treatment have been tried without much success. Pulmonary lavage has been found effective in bringing relief to patients as well as objective amelioration. This presentation describes the technique used and the problems encountered.
In 1958 Rosen, Castleman, and Liebow described 27 patients with a newly-recognized pulmonary disease which they called pulmonary alveolar proteinosis (PAP). Since then approximately 100 cases have been reported. These are reviewed by Davidson and Macleod (1969). Only once has this condition been reported in early infancy. Wilkinson, Blanc, and Hagstrom (1968) described two babies who presented ...
Mice with a functional human immune system have the potential to allow in vivo studies of human infectious diseases and to enable vaccine testing. To this end, mice need to fully support the development of human immune cells, allow infection with human pathogens, and be capable of mounting effective human immune responses. A major limitation of humanized mice is the poor development and functio...
Previous studies have shown that surfactant apoprotein A (SP-A) and natural or synthetic surfactant can modulate the release of pro-inflammatory cytokines from alveolar mononuclear phagocytes. The aim of this study was to assess whether SP-A or Surfactant (Surf) from patients with pulmonary alveolar proteinosis (PAP) can affect the release of two chemokines (interleukin (IL)-8 and monocyte chem...
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