A new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or ethyl acetoacetate and an excess of ammonium acetate under reflux in acetic acid. Similarly, two novel bipyridine derivatives were prepared by the above reaction using terephthaldehyde in lieu of benzaldehyde derivatives. In additio...

Synthesis and reporting of new nanoparticles with diverse properties is important in chemistry. A one-step, rapid controllable synthesis the Fe 3 O 4 surrounded Ti-MOF nanostructures was carried out microwave technology. After identifying confirming structure, used as a suitable catalyst high thermal resistance recyclable three-component reaction phenylhydrazine, malononitrile aldehyde to novel...

the interaction of fe2+ ion with pyrazole was theoretically studied by gussian 03, software at hf/(lanl2dz+6-31g) and hf/ (lanl2dz+6-31g (d)) levels in gas phase and solution. in this study acompartion between optimized structures of pyrazole molecule in aspect of thermodynamicparameters such as enthalpy (h°), gibbs free energy (g°) and entropy (s°) in presence of metallic ion(fe2+), was perfor...

The interaction of Fe2+ ion with Pyrazole was theoretically studied by Gussian 03, software at HF/(LanL2DZ+6-31G) and HF/ (LanL2DZ+6-31G (d)) levels in gas phase and solution. In this study acompartion between optimized structures of Pyrazole molecule in aspect of thermodynamicparameters such as enthalpy (H°), Gibbs free energy (G°) and entropy (S°) in presence of metallic ion(Fe2+), was perfor...

Inflammation forms the part of various diseased conditions. To treat inflammation variety of anti inflammatory agents are synthesized, they showed undesirable side effects. In order to avoid these side effects, nonsteroidal anti-inflammatory drugs were developed. Research is a continuous and never ending process; efforts are being made to improve the present drug profile such that present side ...

derivatives (Fig. 1) that showed in vitro and in vivo antitumor activity. These compounds were also found to inhibit tubulin polymerization as a mechanism of their action in cells. To investigate the possibilities for modification of this scaffold, we divided the moieties into five parts from A to E as shown in Fig. 1. So far, it has been reported that the length of the three carbon chain on mo...

The bifunctional pyrazolopyridine (2) and pyrano-pyrazole (3) derivatives were prepared by the reaction of 2-(2,4-dinitrophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (1) with p-methoxybenzaldehyde, malononitrile in the presence of ammonium acetate or piperidine, respectively. Compound 2 was used as the key intermediate to prepare the pyrazolo-pyrido-pyrimidine derivatives through its reaction ...

A series of thirteen 2-acyl-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole derivatives were synthesized by using a copper-catalyzed azomethine-imine-alkyne cycloaddition as key step. These bimane-related fluorescent compounds with λex = 338–400 nm and λem 522–644 exhibit interesting promising optical properties, including remarkably large Stokes shift (150–268 nm), positive solvatochromism, strong d...

Tyrosine kinase receptor and protein kinases drawn much attention for the scientific fraternity in drug discovery due to its important role in different cancer, cardiovascular diseases and other hyper-proliferative disorders. Docking studies of pyrazole derivatives with tyrosine kinase and different serine/threonine protein kinases were employed by using flexible ligand docking approach of Auto...