To elucidate the mechanism whereby distigmine, an underactive bladder remedy, potentiates urinary bladder contractions long-lastingly, the inhibition of recombinant human acetylcholinesterase (rhAChE) by distigmine was investigated. A centrifugal ultrafiltration device, Nanosep® 10K, was used to separate rhAChE and a bound inhibitor from an unbound inhibitor, reaction substrate, and reaction pr...

anaphylactic reactions can occur following the adminstration of muscle relaxants. however, it happens very rarefy wish pancuronium bromide. a case report of anaphylactic shock to pancuronium bromide, which is supported by a highly poitive skin prick test, is reported.

background postoperative residual blockade, longer duration of action for neuromuscular blockade, and slower recovery were relatively common in elderly patients. objectives we aimed to investigate the safety of train-of-four ratio and clinical tests in the assessment of patient recovery, and to determine the effects of the rocuronium, vecuronium, and cisatracurium on intubation, extubation and ...

BACKGROUND The most sensitive diagnostic criterion of myasthenia gravis is a decrement in the muscular response to repetitive stimulation. The authors hypothesized that myasthenia gravis patients who show a train-of-four ratio (T4/T1) < 0.9 in the preanesthetic period will have increased sensitivity to nondepolarizing neuromuscular blocking agents compared with myasthenia gravis patients with p...

introduction: memory and cognitive impairments are some of devastating outcomes of multiple sclerosis (ms) plaques in hippocampus, the gray matter part of the brain. the present study aimed to evaluate the intrahippocampal injection of ethidium bromide (eb) as a simple and focal model to assess cognition and gray matter demyelination. methods: thirty wistar rats were divided into three groups: ...

Normal cardiovascular regulation requires intact baroreflex regulation. The efferent portion of the baroreflex arc, which is composed of parasympathetic and sympathetic nerves, is particularly important in this regard. Autonomic failure ensues when the efferent arc is interrupted. Neuronal degeneration within the brain or in the periphery,1,2 enzymatic defects in catecholamine synthesis,3 and a...

how to cite this article: talebian a, goudarzi rm, mohammadzadeh m , mirzadeh as. vincristine-induced cranial neuropathy. iran j child neurol. 2014 winter; 8(1):66-68.   abstract vincristine (vcr) is a vinca alkaloid that is used for treatment of many malignancies. the vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects.  de...