Introduction and Aim: An efficient aspect of two step synthesis tetrahydro pyrimidine carboxamide derivatives were developed by Biginelli reaction. The two-step synthesized 1,2,3,4-tetrahydropyrimidinecarboxamide compounds evaluated In-vitro studies like antifungal bacterial activities. Few shown excellent zone inhibition against fungal Microbial In this study showed significant effect action d...

Abstract: Background: Search for the better anti-cancer agents become central part many research teams as current drugs in use suffer lack of specificity to cancer targets. Design and development target specific increase potency safety drugs. Materials Methods: Current intends develop a novel series pyrimidine derivatives owing potential scaffold. In multicomponent reaction approach, 4,5-disubs...

A Derivatives of 2-thiouracil are characteri­zed by wide spectrum biological activity, which is characteristic most representatives this heterocycles class. In particular, 2-(2-oxo-2-phenylethylthio)-pyrimi­din-4(3H)-ones belong to the group non-nucleoside inhibitors HIV-1 reverse transcriptase. The antimalarial properties 2-(2-oxo-2-phenylethyl­thio)-4-R-pyrimidine derivatives, proved be effec...

Several new tracers are being developed for use with PET to assess pathways that are altered in cancers, including energy use, cellular signaling, transport, and proliferation. Because increased proliferation is a hallmark of many cancers, several tracers have been tested to track the DNA synthesis pathway. Thymidine, which is incorporated into DNA but not RNA, has been used in laboratory studi...

[This corrects the article on p. 403 in vol. 40.].

The study of the action of ferrous bicarbonate plus air on the pyrimidinesl has been continued and the chemical change in the pyrimidine ring examined in more detail. If an aqueous solution of cytosine is treated with the system ferrous sulfate plus sodium bicarbonate plus air, hydrolysis of the amino group occurs with the formation of uracil and the liberation of ammonia. Since uracil is forme...