Interindividual differences in chromatin states at a locus (epialleles) can result in gene expression changes that are sometimes transmitted across generations. In this way, they can contribute to heritable phenotypic variation in natural and experimental populations independent of DNA sequence. Recent molecular evidence shows that epialleles often display high levels of transgenerational insta...

drying foodstuffs can have negative effects on quantitative and qualitative characteristics of the products, including porosity and bulk density. therefore, novel technologies can be used to improve these characteristics. in this study, apparent density changes during drying grapes pretreated with ultrasound for 10, 20 and 30 minutes, and carboxymethyl cellulose (cmc) at three concentrations of...

toxicity of 38 aliphatic carboxylic acids was studied using non-linear quantitative structure-toxicityrelationship (qstr) models. the adaptive neuro-fuzzy inference system (anfis) was used to construct thenonlinear qstr models in all stages of study. two anfis models were developed based upon differentsubsets of descriptors. the first one used log ow k and lumo e as inputs and had good predicti...

Several gradient-echo fMRI blood oxygenation level-dependent (BOLD) effects are described in the literature: extravascular spin dephasing around capillaries and veins, intravascular phase changes, and transverse relaxation changes of blood. This work considers a series of tissue compartmentalized models incorporating each of these effects, and tries to determine the model which is most consiste...

Robert B. Stone† Basic Engineering Department University of Missouri-Rolla Rolla, MO 65409-0210 [email protected] Kristin L. Wood Department of Mechanical Engineering The University of Texas at Austin Austin, TX 78712 [email protected] Richard H. Crawford Department of Mechanical Engineering The University of Texas at Austin Austin, TX 78712 [email protected] PRODUCT ARCHITECTURE DEVELOPMENT ...

When developing a safety-critical system it is essential to obtain an assessment of different design alternatives. In particular, an early safety assessment of the architectural design of a system is desirable. In spite of the plethora of available formal quantitative analysis methods it is still difficult for software and system architects to integrate these techniques into their every day wor...

Most research on computational scientific discovery has focused on developing an initial model, but an equally important task involves revising a model in response to new data. In this paper, we present an approach that represents candidate models as sets of quantitative processes and that treats revision as search through a model space which is guided by time-series observations and constraine...

We introduce a class of coalgebraic models and a family of modal logics that support the speci cation of spatial properties of distributed applications. The evaluation of a formula yields a value in a suitable multi-valued algebraic structure, giving a measure of the satisfaction of a requirement, induced by the decomposition of a system into subsystems, meant as available resources. As semanti...

Pattern formation in developing organisms can be regulated at a variety of levels, from gene sequence to anatomy. At this level of complexity, mechanistic models of development become essential for integrating data, guiding future experiments, and predicting the effects of genetic and physical perturbations. However, the formulation and analysis of quantitative models of development are limited...